Method of inhibiting cardiac arrhythmias

• US 4,554,922 A
• Filed: 09/30/1982
• Issued: 11/26/1985
• Est. Priority Date: 09/30/1982
• Status: Expired due to Term

• Current Assignee: Eric N. Prystowsky, Zipes, Douglas P.
• Original Assignee: Eric N. Prystowsky, Zipes, Douglas P.
• Inventors: Prystowsky, Eric N., Zipes, Douglas P.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US06/429,827
• Time in Patent Office: 1,153 Days
• Field of Search: 128/419 PG, 128/419 D
• US Class Current: 607/14
• CPC Class Codes: A61N 1/3621 for treating or preventing abnormally high heart rate
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/3918 characterised by shock pathway, e.g. by electrode configuration

Abstract

Inhibition of cardiac arrhythmias such as tachycardia and fibrillation is achieved by determining a refractory period after a selected heartbeat during which a stimulus applied to the heart will not propagate a heart response, determining a time within the refractory period after the selected heartbeat for the application of one or more electrical pulses to the heart to inhibit arrhythmic beats, determining a voltage of the electrical pulse as a function of the time which will inhibit the arrhythmic beats, and applying the electrical pulse to an area of the heart at the determined time to inhibit the arrhythmic beats. A plurality of electrical pulses may be employed having various voltage levels related to the times at which they are applied during the refractory period. One or more electrical pulses may be applied after the refractory period, each having a voltage providing a current less than a threshold current which would propagate a heart response.

Claims

1. In a method of pacing a heart, which includes the step of applying electrical stimuli to the heart to propagate rhythmic responses, the improvement comprising the steps of determining a characteristic refractory time period between a patient'"'"'s rhythmic responses within which an electrical stimulus can be applied to the patient'"'"'s heart without propagating a heart response, sensing each rhythmic heart response, determining a time within the refractory time period after each sensed rhythmic heart response for the application of an electrical stimulus to the heart, after each rhythmic heart response, generating a conditioning electrical stimulus having an amplitude which is a function of the determined time so that it will not propagate a heart response, and applying the conditioning electrical stimulus to the patient'"'"'s heart at the determined time during the refractory time period after the sensed rhythmic heart response to inhibit a subsequent spontaneous arrhythmic response before the next rhythmic heart response.

2. A method of inhibiting cardiac arrhythmias before they occur comprising the steps of determining a characteristic refractory time period between a patient'"'"'s heartbeats within which an electrical stimulus can be applied to the patient'"'"'s heart without propagating a heart response, sensing each beat of the patient'"'"'s heart;

after each sensed heartbeat, generating an electrical pulse having an amplitude which will not propagate a heart response, and applying the electrical pulse to a portion of the patient'"'"'s heart during the refractory time period after each sensed heartbeat to inhibit a subsequent spontaneous arrhythmic beat before it occurs.

3. The method of claim 2 further comprising the step of, before generating the electrical pulse, determining a time within the refractory time period after each sensed heartbeat when the pulse is to be applied.

4. The method of claim 3 wherein the step of generating the electrical pulse includes generating an electrical pulse having a predetermined duration and an amplitude that is a function of the predetermined duration.

5. The method of claim 3 wherein the step of generating the electrical pulse includes generating an electrical pulse having an amplitude that is a function of the determined time.

6. The method of claim 5 wherein the step of generating the electrical pulse further includes generating an electrical pulse having a predetermined duration and an amplitude that is a function of the predetermined duration.

7. The method of claim 6 wherein the determined time is less than the characteristic refractory time period of the patient'"'"'s heartbeats.

8. The method of claim 2 comprising the steps of, after each sensed heartbeat, generating a plurality of electrical pulses each having an amplitude and duration that will not propagate a heart response and applying the electrical pulses to portions of the patient'"'"'s heart during the refractory time period after each heartbeat to inhibit spontaneous arrhythmic beats before they occur.

9. The method of claim 8 comprising the step of, before generating the plurality of electrical pulses, determining a plurality of times during the refractory time period after each sensed heartbeat when the electrical pulses are to be applied.

10. The method of claim 9 wherein the step of generating the plurality of electrical pulses includes generating a plurality of electrical pulses having an amplitude that is a function of the determined time when it is to be applied.

11. The method of claim 2 further comprising the step of disposing a plurality of electrodes at various areas of the heart and applying the electrical pulse to each electrode.

12. The method of claim 11 wherein the step of applying the electrical pulse includes applying the electrical pulse simultaneously to the electrodes.