Ultrasonic coagulation monitor and method

• US 4,558,589 A
• Filed: 10/09/1984
• Issued: 12/17/1985
• Est. Priority Date: 10/09/1984
• Status: Expired due to Fees

• Current Assignee: Miles Laboratories Incorporated A Corporation Del
• Original Assignee: Miles Laboratories, Inc. (Bayer AG)
• Inventors: Hemmes, Paul R.
• Primary Examiner(s): Levy, Stewart J.
• Assistant Examiner(s): ROSKOS, JOSEPH
• Application Number:
  US06/659,173
• Time in Patent Office: 434 Days
• Field of Search: 73/64.1, 374/16, 374/23
• US Class Current: 73/64.42
• CPC Class Codes: A61B 8/485 involving measuring strain or elastic properties
• CPC Class Codes: G01N 2291/0256 Adsorption, desorption, surface mass change, e.g. on biosensors
• CPC Class Codes: G01N 29/036 by measuring frequency or resonance of acoustic waves
• CPC Class Codes: G01N 33/4905 Determining clotting time of blood by chemical methods G01N33/86, C12Q1/54
• CPC Class Codes: G01N 33/86 involving blood coagulating time or factors, or their receptors

Abstract

An ultrasonic coagulation monitor for measurement of prothrombin times and related coagulation times includes at least one piezoelectric crystal operated at a fixed frequency near its resonant frequency. A sample of material to be analyzed is placed in acoustic communication with the crystal. The voltage across the crystal is monitored in order to detect a voltage change, preferably a drop, that occurs upon coagulation of the sample. A timer is included that is turned off at a predetermined voltage drop corresponding to a particular stage of coagulation desired to be timed. In an alternative embodiment of the invention a second crystal is included and is mounted a predetermined distance from the first crystal to define a cavity therebetween. One crystal is driven by the frequency oscillator circuit and the material the coagulation of which is to be measured is placed in the cavity. A voltage sensing device senses the voltage across the second crystal and controls a timer as in the first embodiment.

Claims

1. A ultrasonic coagulation monitor, comprising:

a housing,

at least one piezoelectric crystal mounted in said housing,

means for driving said crystal at a fixed frequency,

a timer, and

means for measuring resonant voltage in a circuit defined by said crystal and said driving means and for turning off said timer upon said voltage dropping to a predetermined level.

2. The ultrasonic coagulation monitor set forth in claim 1 wherein said piezoelectric crystal is operated in a shear mode of resonance.

3. The ultrasonic coagulation monitor set forth in claim 1 wherein said piezoelectric crystal comprises an AT cut quartz crystal.

4. The ultrasonic coagulation monitor set forth in claim 1 wherein said crystal is a lithium niobate crystal.

5. The ultrasonic coagulation monitor set forth in claim 1 wherein said crystal is circular in configuration.

6. The ultrasonic coagulation monitor set forth in claim 1 wherein the fundamental frequency of said crystal is in the range of 5-20 MHz.

7. The ultrasonic coagulation monitor set forth in claim 1 further comprising a second crystal mounted in said housing spaced a predetermined distance from said first crystal to define a resonant cavity between said first and second crystals.

8. The ultrasonic coagulation monitor set forth in claim 1 further comprising a cover for said housing.

9. The ultrasonic coagulation monitor set forth in claim 1 further comprising means for maintaining the temperature in said housing at approximately 37°

C.

10. The ultrasonic coagulation monitor set forth in claim 1 wherein said housing includes means for supporting said crystal including pin points.

11. The ultrasonic coagulation monitor set forth in claim 1 wherein said housing includes means for supporting said crystal including a sharp edge.

12. The ultrasonic coagulation monitor set forth in claim 1 further comprising supports in said housing supporting said crystal wherein said supports are Teflon coated.

13. The ultrasonic monitor set forth in claim 1 wherein said resonant voltage measuring means includes a voltage comparator.

14. A device for measuring coagulation times, comprising:

at least one piezoelectric crystal,

means for supporting each said crystal to allow each said crystal to oscillate in the plane of each said crystal,

means for defining with said crystal a fixed frequency oscillator circuit,

a timer, and

means for measuring a change in resonance voltage in said oscillator circuit and for turning off said timer upon said resonance voltage changing to a predetermined value.

15. The device claimed in claim 14 further comprising a housing, each said at least one crystal being mounted in said housing.

16. The device claimed in claim 14 further comprising means for maintaining the temperature in said housing at approximately 37°

C.

17. The device claimed in claim 14 wherein said oscillator circuit includes a fixed frequency generator with a resonant frequency of 5-20 MHz.

18. The device claimed in claim 14 wherein each said at least one crystal is a quartz crystal cut along the Y axis and each is of a fundamental frequency of 5-20 MHz.

19. The device claimed in claim 14 wherein said measuring means includes an impedance analyzer.

20. The device claimed in claim 14 wherein said supporting means comprises pin points.

21. The device claimed in claim 14 further comprising a second crystal supported by said supporting means a predetermined distance from said at least one crystal to define a cavity therebetween.

22. The device claimed in claim 14 wherein each said crystal includes evaporated electrodes.

23. An ultrasonic coagulation monitor, comprising:

a pair of piezoelectric crystals;

means for mounting said crystals a predetermined distance apart to define a cavity therebetween;

means for energizing at least one of said crystals with a fixed frequency oscillator circuit;

a timer; and

means for sensing a voltage at the other of said piezoelectric crystals and turning off said timer upon said voltage reaching a predetermined amplitude.

24. The monitor set forth in claim 23 wnerein said mounting means includes a housing and means for heating said cavity to 37°

C.

25. The monitor set forth in claim 23 wherein said voltage sensing means includes a voltage comparator.

26. The monitor set forth in claim 23 wherein said crystals comprise AT cut quartz crystals.

27. A method of monitoring coagulation times of material comprising the steps of:

placing material, the coagulation time of which is to be measured, in sound absorbing relationship with at least one piezoelectric crystal;

driving said at least one crystal at a fixed frequency using a fixed frequency oscillator circuit;

detecting a predetermined voltage change in said oscillator circuit; and

determining the time required for the voltage change to occur.

28. The method set forth in claim 27 further comprising the step of maintaining the temperature of said material at 37°

C.

29. The method set forth in claim 27 further comprising the step of driving said at least one crystal at 5-20 MHz.