Substituted 4-aminomethylene-chromans and -chromenes, processes for their preparation and their use in medicaments
First Claim
1. A compound of the formula (I) ##STR140## in which --A-- represents a single bond or a double bond, andR1 and R2 are identical or different and represent hydrogen, C1 -C6 -alkyl, C5 -C7 -cycloalkyl, phenyl which is optionally substituted by C1 -C4 -alkyl, halogen and/or C1 -C4 -alkoxy, or C7 -C9 -aralkyl, whose aryl radical is optionally substituted by C1 -C4 -alkyl, halogen and/or C1 -C4 -alkoxy, or R1 and R2 conjointly with the enclosed C atom of the chroman ring form a 4-membered to 7-membered carbocyclic ring;
- R3 to R6 are identical or different and represent hydrogen, hydroxyl, halogen, C1 -C6 -alkyl, C5 -C7 -cycloalkyl, phenyl which is optionally substituted by C1 -C4 -alkyl, halogen, and/or C1 -C4 -alkoxy, C7 -C9 -aralkyl, whose aryl radical is optionally substituted by C1 -C4 -alkyl, halogen and/or C1 -C4 -alkoxy, or C1 -C4 -alkoxy,R7, R8, R9, R10 and R11 are identical or different and represent hydrogen or C1 -C6 -alkyl,X represents a single bond or methylene which is optionally monosubstituted or disubstituted by C1 -C4 -alkyl, oxygen or --NR17,whereinR17 represents hydrogen or C1 -C4 -alkyl or R17 together with R7 forms a C2 -alkylene ring-closing member andR12, R13, R14, R15 and R16 are identical or different and represent hydrogen, hydroxyl, halogen, C1 -C6 -alkyl, C5 - or C6 -cycloalkyl, benzyl, C1 -C4 -alkoxy, trifluoromethyl, or R12 and R13 or R13 and R14 together form a C1 -C3 -alkylenedioxy group or a --CH═
CH--CH═
CH-- group, and their pharmaceutically acceptable acid addition salts.
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Abstract
The invention relates to substituted 4-aminomethylene-chromans and chromens of Formula (I) infra, as well as methods for making of said chromans and chromens, compositions containing said chromans and chromens and methods for the use of said chromans, chromens and compositions containing said chromans and chromens. The compounds and compositions of the invention are useful for their circulation influencing activity.
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Citations
18 Claims
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1. A compound of the formula (I) ##STR140## in which --A-- represents a single bond or a double bond, and
R1 and R2 are identical or different and represent hydrogen, C1 -C6 -alkyl, C5 -C7 -cycloalkyl, phenyl which is optionally substituted by C1 -C4 -alkyl, halogen and/or C1 -C4 -alkoxy, or C7 -C9 -aralkyl, whose aryl radical is optionally substituted by C1 -C4 -alkyl, halogen and/or C1 -C4 -alkoxy, or R1 and R2 conjointly with the enclosed C atom of the chroman ring form a 4-membered to 7-membered carbocyclic ring; -
R3 to R6 are identical or different and represent hydrogen, hydroxyl, halogen, C1 -C6 -alkyl, C5 -C7 -cycloalkyl, phenyl which is optionally substituted by C1 -C4 -alkyl, halogen, and/or C1 -C4 -alkoxy, C7 -C9 -aralkyl, whose aryl radical is optionally substituted by C1 -C4 -alkyl, halogen and/or C1 -C4 -alkoxy, or C1 -C4 -alkoxy, R7, R8, R9, R10 and R11 are identical or different and represent hydrogen or C1 -C6 -alkyl, X represents a single bond or methylene which is optionally monosubstituted or disubstituted by C1 -C4 -alkyl, oxygen or --NR17, wherein R17 represents hydrogen or C1 -C4 -alkyl or R17 together with R7 forms a C2 -alkylene ring-closing member and R12, R13, R14, R15 and R16 are identical or different and represent hydrogen, hydroxyl, halogen, C1 -C6 -alkyl, C5 - or C6 -cycloalkyl, benzyl, C1 -C4 -alkoxy, trifluoromethyl, or R12 and R13 or R13 and R14 together form a C1 -C3 -alkylenedioxy group or a --CH═
CH--CH═
CH-- group, and their pharmaceutically acceptable acid addition salts. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification
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- Resources
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Current AssigneeBayer AG
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Original AssigneeBayer AG
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InventorsKnorr, Andreas, Widdig, Arno, Benz, Ulrich, Kabbe, Hans-Joachim
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Primary Examiner(s)Hollrah, Glennon H.
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Assistant Examiner(s)Turnipseed, James H.
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Application NumberUS06/560,786Time in Patent Office756 DaysField of Search544/376, 544/377, 544/250, 544/230, 549/330, 549/406, 549/407, 549/345, 549/350, 549/383, 549/387, 549/389, 260/330.9, 424/250, 514/253, 514/450, 514/452, 514/457US Class Current514/254.11CPC Class CodesA61P 9/12 AntihypertensivesC07D 311/58 other than with oxygen or s...C07D 311/60 with aryl radicals attached...C07D 311/96 spiro-condensed with carboc...C07D 407/12 linked by a chain containin...C07F 7/1804 Compounds having Si-O-C lin...
