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Substituted 4-aminomethylene-chromans and -chromenes, processes for their preparation and their use in medicaments

  • US 4,563,458 A
  • Filed: 12/13/1983
  • Issued: 01/07/1986
  • Est. Priority Date: 01/03/1983
  • Status: Expired due to Fees
First Claim
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1. A compound of the formula (I) ##STR140## in which --A-- represents a single bond or a double bond, andR1 and R2 are identical or different and represent hydrogen, C1 -C6 -alkyl, C5 -C7 -cycloalkyl, phenyl which is optionally substituted by C1 -C4 -alkyl, halogen and/or C1 -C4 -alkoxy, or C7 -C9 -aralkyl, whose aryl radical is optionally substituted by C1 -C4 -alkyl, halogen and/or C1 -C4 -alkoxy, or R1 and R2 conjointly with the enclosed C atom of the chroman ring form a 4-membered to 7-membered carbocyclic ring;

  • R3 to R6 are identical or different and represent hydrogen, hydroxyl, halogen, C1 -C6 -alkyl, C5 -C7 -cycloalkyl, phenyl which is optionally substituted by C1 -C4 -alkyl, halogen, and/or C1 -C4 -alkoxy, C7 -C9 -aralkyl, whose aryl radical is optionally substituted by C1 -C4 -alkyl, halogen and/or C1 -C4 -alkoxy, or C1 -C4 -alkoxy,R7, R8, R9, R10 and R11 are identical or different and represent hydrogen or C1 -C6 -alkyl,X represents a single bond or methylene which is optionally monosubstituted or disubstituted by C1 -C4 -alkyl, oxygen or --NR17,whereinR17 represents hydrogen or C1 -C4 -alkyl or R17 together with R7 forms a C2 -alkylene ring-closing member andR12, R13, R14, R15 and R16 are identical or different and represent hydrogen, hydroxyl, halogen, C1 -C6 -alkyl, C5 - or C6 -cycloalkyl, benzyl, C1 -C4 -alkoxy, trifluoromethyl, or R12 and R13 or R13 and R14 together form a C1 -C3 -alkylenedioxy group or a --CH═

    CH--CH═

    CH-- group, and their pharmaceutically acceptable acid addition salts.

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