Composite polymeric material for biological and medical application and the method for its preparation

• US 4,563,490 A
• Filed: 11/18/1983
• Issued: 01/07/1986
• Est. Priority Date: 07/21/1980
• Status: Expired due to Fees

• Current Assignee: Ceskoslovenska Akademie VED of Praha Czechoslovakia
• Original Assignee: Czechoslovenska Akademie VED of Praha
• Inventors: Kalal, Jaroslav, Cefelin, Pavel, Adam, Milan, Tolar, Miroslav, Stol, Miroslav
• Primary Examiner(s): Kight, John
• Assistant Examiner(s): NOT, DEFINED
• Application Number:
  US06/553,859
• Time in Patent Office: 781 Days
• Field of Search: 523/105, 523/106, 523/113, 523/114, 524/21, 524/24, 524/498, 524/460, 524/845, 525/54.1, 525/937, 351/160 H, 260/123.7
• US Class Current: 524/24
• CPC Class Codes: A61L 15/225 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 33/0011 Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
• CPC Class Codes: C08L 2666/02 Organic macromolecular compounds, natural resins, waxes or and bituminous materials
• CPC Class Codes: C08L 33/08 Homopolymers or copolymers of acrylic acid esters
• CPC Class Codes: C08L 89/04 Products derived from waste materials, e.g. horn, hoof or hair
• CPC Class Codes: C08L 89/06 derived from leather or skin , e.g. gelatin
• CPC Class Codes: C12N 2533/30 Synthetic polymers
• CPC Class Codes: C12N 2533/54 Collagen; Gelatin
• CPC Class Codes: C12N 5/0068 General culture methods using substrates for specific animal cell type C12N5/06
• CPC Class Codes: Y10S 128/08 Collagen
• CPC Class Codes: Y10S 525/937 Utility as body contact e.g. implant, contact lens or I.U.D.

Abstract

The invention relates to a composite polymeric material suitable for biological and medical applications and to the method for preparation thereof. The composite material consists of 1-99 wt. % of hydrophilic polymer or copolymer based on methacrylic or acrylic esters, 1-99 wt. % of fibrillar collagen, and up to 2.5 wt. % of a crosslinking agent, based on both polymeric components. The composite material may further comprise biologically active compounds and other auxiliary materials, as fillers and/or plasticizers. The composite material is prepared by dispersing the fibrillar collagen in a solution or a highly swollen dispersion of the synthetic hydrophilic polymer or copolymer in a lytropic agent and the subsequent removal of the lyotropic agent, thus forming a matrix of the synthetic polymer or copolymer penetrated by fibrillar collagen or vice versa. The composite material may be applied on a solid support or reinforced with glass, plastics, cellulose, or metallic materials.

Claims

1. Composite polymeric material for biological and medical application comprising a matrix of at least the following components:

1-99 weight percent of a substantially water insoluble hydrophilic polymer or copolymer based on methacrylate or acrylate, 1-99 weight percent of a fibrillar collagen, 0-2.5 weight percent of a crosslinking agent, related to both polymeric components, said material being prepared by dispersing the fibrillar collagen in a solution or in a high swollen dispersion of the synthetic hydrophilic polymer or copolymer in a lyotropic agent which maintains the mutual miscibility of said components and by the subsequent removal of the lyotropic agent forming a matrix of said synthetic polymer or copolymer interpregnated with collagen or a matrix of collagen interpregnated with said synthetic polymer or copolymer.

2. The composite polymeric material according to claim 1 wherein said hydrophilic polymer or copolymer has a molecular weight in the range of from 10⁴ to 10⁶.

3. The composite polymeric material according to claim 1 including at least one biologically active compound.

4. The composite polymeric material according to claim 1 including an auxiliary material selected from the group consisting of plasticisers and fillers.

5. The composite material according to claim 1 wherein said material is applied on a solid base.

6. The composite material according to claim 1 wherein said material is reinforced with a solid material selected from the group comprising glass, plastics, cellulose and metals.