Delayed action assembly

• US 4,564,363 A
• Filed: 07/13/1983
• Issued: 01/14/1986
• Est. Priority Date: 07/13/1983
• Status: Expired due to Fees

• Current Assignee: Smithkline Beecham Corporation (GSK plc)
• Original Assignee: Smithkline Beecham Corporation (GSK plc)
• Inventors: Gyurik, Robert J., Bagnall, Brian G.
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): Costantino, Mario
• Application Number:
  US06/513,512
• Time in Patent Office: 916 Days
• Field of Search: 604/890, 604/891, 604/93, 604/131, 604/140-143, 604/145, 604/403, 128/630, 128/631, 222/3, 222/5, 222/638, 222/639, 222/641, 222/644, 222/642, 102/215, 102/367, 102/368
• US Class Current: 604/891.1
• CPC Class Codes: A61D 7/00 Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals for reproduction or fertilisation A61D19/00 ; devices for implanting pellets, radon seeds or the like A61M37/0069
• CPC Class Codes: A61K 9/0068 Rumen, e.g. rumen bolus
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A device for effecting the delayed release of an active ingredient comprises a container and, within, a dispersible unit of ingredient, a removable closure and a electrical control circuit for removal of said closure at a designated time to release the active ingredient. Several assemblies are combined to control the administration of veterinary medicaments to ruminant animals as a specific application of the invention.

Claims

1. A delayed release, ruminant dosage form comprising from 1 to 4 dosage unit release assemblies, at least one of which is a delayed action assembly which, in turn, comprises;

a closed, non-biodegradable outer wall;

a dosage unit of an active ingredient in dispersible form within said wall;

a water-tight cover or plug which is capable of being displaced by internal gas pressure and which extends through said outer wall;

weight means sufficient to retain said delayed action assembly in the rumen and arranged within said dosage form, and

an internally disposed electrical circuit means which, in turn, comprises, interconnected;

a source of current;

an internally disposed chemical squib for generating internal gas pressure, within the assembly,

sufficient to remove said removable cover or plug;

means for timing and activating said chemical squib, and

means for activating said circuit.

2. The dosage form of claim 1 in which the chemical squib is comprised of barium styphnate.

3. The dosage form of claim 1 in which the means for activating the electrical circuit is two wires completing the conductivity circuit by means of reumen content, said wires being exposed to said rumen content on the surface of the form.

4. The dosage form of claim 1 in which the non-biodegradable wall material is a polyethylene of polypropylene polymer.

5. The dosage form of claim 1 in which the active ingredient is an anthelmintic.

6. The dosage form of claim 1 in which the active ingredient is albendazole.

7. The dosage form of claim 1 for release of an active ingredient, in which said electrical circuit means comprising a source of current, which is sufficient to activate and operate said timing means and said chemical squib, as well as a switch means for activating said electrical circuit means are all disposed within said assembly.

8. The dosage form of claim 1 in which three assemblies are present, each timed to release its active ingredient at a preset period.