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Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same

  • US 4,567,183 A
  • Filed: 12/12/1983
  • Issued: 01/28/1986
  • Est. Priority Date: 03/11/1983
  • Status: Expired due to Fees
First Claim
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1. A method of eliciting an onset hastened and enhanced analgesic and anti-inflammatory response in a mammalian organism in need of such treatment, comprising administering to such organism:

  • (i) an analgesically and anti-inflammatorily effective amount of benoxaprofen, flurbiprofen, fenbufen, ketoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, tiaprofenic acid, fluprofen, bucloxic acid, or pharmaceutically acceptable salts thereof, and(ii) an amount of xanthine derivative sufficient to hasten the onset of and enhance the analgesic and anti-inflammatory response of component (i), said xanthine derivative having the formula;

    ##STR61## or a pharmaceutically acceptable non-toxic salt thereof wherein R1 -R3, inclusive, independently represent hydrogen, C1 -C6 alkyl, C1 -C6 alkoxy, C1 -C6 haloalkyl, C3 -C6 cycloalkyl, hydroxy (C1 -C6)alkyl, halogen, hydroxy(C1 -C4)alkylamino(C1 -C4)alkyl, C1 -C4 (dialkyl)amino(C1 -C4)alkyl, C1 -C4 alkylcarbonyl(C1 -C4)alkyl, C1 -C6 alkylamino, C1 -C6 (dialkyl)amino, indolyl, phenyl or allyl;

    R4 is hydrogen, C1 -C6 alkyl, halo(C1 -C6)alkyl, C1 -C6 alkylamino, C1 -C6 alkylthio, nitro, carboxy C1 -C6 (dialkyl)amino, C3 -C6 cycloalkyl, phenyl, naphthyl, ar(C1 -C4)alkyl, or a group of the formula ##STR62## where R5 is halo, C1 -C6 alkyl, C1 -C6 alkoxy, C1 -C6 alkylthio, nitro or C1 -C6 alkylamino, and n is 1, 2 or 3with the proviso that R1, R2 and R3 cannot all be C1 alkyl when R4 is hydrogen.

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