Composition for periodontal administration

• US 4,568,535 A
• Filed: 07/16/1984
• Issued: 02/04/1986
• Est. Priority Date: 08/06/1982
• Status: Expired due to Term

• Current Assignee: Walter J. Loesche
• Original Assignee: Walter J. Loesche
• Inventors: Loesche, Walter J.
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): NOT, DEFINED
• Application Number:
  US06/631,542
• Time in Patent Office: 568 Days
• Field of Search: 424/22, 424/26, 424/28, 424/19, 424/273 R, 424/52, 106/35, 514/365
• US Class Current: 424/435
• CPC Class Codes: A61K 9/0063 Periodont

Abstract

A composition for periodontal administration and a method of periodontal treatment involving a slow release device which can be placed directly into the periodontal pocket where metronidazole, with or without antioxidants, are released over periods of days to weeks at a cidal concentration for anaerobes in the domain of the periodontal pocket.

Claims

1. A film contoured to be cut to approximate the dimension of a periodontal pocket for the treatment of bacterial infections of the periodontum wherein the film consists essentially of a mixture of:

80 to 98 parts by weight of ethylcellulose, 1 to 20 parts by weight of metronidazole, 0.1 to 1 part by weight of an antioxidant selected from the group consisting of ascorbic acid, sodium thiosulfate, dithiothreitol, cysteine, thioglycollate and glutathione.

2. A method of inhibiting the growth of a bacterial infection of the periodontum by placing locally into the periodontal pocket an antibacterial effective amount of the film of claim 1.