Imidazo[1,2-b]pyridazines

• US 4,569,934 A
• Filed: 10/09/1984
• Issued: 02/11/1986
• Est. Priority Date: 10/09/1984
• Status: Expired due to Term

• Current Assignee: American Colloid Company (Minerals Technologies Incorporated)
• Original Assignee: American Colloid Company (Minerals Technologies Incorporated)
• Inventors: Powell, Dennis W., Albright, Jay D., Moran, Daniel B.
• Primary Examiner(s): Daus, Donald G.
• Assistant Examiner(s): Kapner, Stephen M.
• Application Number:
  US06/658,716
• Time in Patent Office: 490 Days
• Field of Search: 544/236, 514/248
• US Class Current: 514/248
• CPC Class Codes: C07D 241/20 Nitrogen atoms nitro radicals C07D241/16
• CPC Class Codes: C07D 487/04 Ortho-condensed systems

Abstract

This invention concerns novel imidazo[1,2-b]-pyridazines and their use as agents for treating anxiety.

Claims

1. A compound of the formula:

##STR7## wherein R₁ is selected from the group consisting of hydrogen and lower alkyl having from 1 to 3 carbon atoms; and

R₂ is selected from the group consisting of 3-pyridinyl and [3-(trifluoromethyl)phenyl] and the pharmacologically acceptable acid-addition salts thereof.

2. The compound, according to claim 1, 3-methyl-6-[3-(trifluoromethyl)phenyl]imidazo[1,2,-b]pyridazine.

3. The compound, according to claim 1, 3-methyl-6-(3-pyridinyl)imidazo[1,2,-b]pyridazine.

4. The compound, according to claim 1, 2-methyl-6-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine.

5. The compound, according to claim 1, 2-ethyl-6-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine.

6. The compound, according to claim 1, 6-[3-(trifluoromethyl)phenyl]imidazo[1,2,-b]pyridazine.

7. The compound, according to claim 1, 6-(3-pyridinyl)imidazo[1,2-b]pyridazine.

8. The compound, according to claim 1, 2-methyl-6-(3-pyridinyl)imidazo[1,2-b]pyridazine.

9. The compound, according to claim 1, 3-ethyl-6-(3-pyridinyl)imidazo[1,2-b]pyridazine.

10. The compound, according to claim 1, 3-propyl-6-[3-(trifluoromethyl)phenyllimidazo[1,2-b]pyridazine.

11. The compound, according to claim 1, 2-propyl-6-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine.

12. The compound, according to claim 1, 2-methyl-6-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine, hydrobromide.

13. A method of meliorating anxiety in a mammal which comprises administering internally to said mammal a therapeutically effective amount of a compound of the formula as recited in claim 1.

14. An antianxiety composition of matter in dosage unit form which comprises a compound of the formula as recited in claim 1 in association with a pharmaceutically acceptable carrier.

15. An antianxiety composition of matter in dosage unit form which comprises a compound of the formula as recited in claim 1 in association with a pharmaceutically acceptable carrier and adjuvant.