Contact agents for ultrasonic imaging

• US 4,572,203 A
• Filed: 01/27/1983
• Issued: 02/25/1986
• Est. Priority Date: 01/27/1983
• Status: Expired due to Term

• Current Assignee: SLF Limited Partnership
• Original Assignee: Steven B. Feinstein
• Inventors: Feinstein, Steven B.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): Jaworski, Francis J.
• Application Number:
  US06/461,664
• Time in Patent Office: 1,125 Days
• Field of Search: 128/660-663, 424/1, 424/4, 73/861.25, 73/861.41
• US Class Current: 424/9.52
• CPC Class Codes: A61B 2090/3925 ultrasonic
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: A61K 49/223 Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
• CPC Class Codes: G01S 15/899 Combination of imaging systems with ancillary equipment

Abstract

A method of ultrasonic imaging for use in medical procedures is disclosed. The method comprises injecting specifically defined microparticles or sonicated microbubbles into an animal or human to thereby alter the acoustic properties of an area to be imaged, and then ultrasonically scanning the area so as to obtain an image.

Claims

1. A method of ultrasonic imaging for use in medical procedures, comprising the steps of:

(a) injecting biodegradable, metal-containing microparticles into a mammal to thereby alter the acoustic properties of a predetermined area; and

(b) ultrasonically scanning an area including said predetermined area so as to obtain an image of said predetermined area.

2. The method according to claim 1 wherein said microparticles have an average diameter of less than 1.5 microns and are formed from an amino acid polymer matrix with magnetic iron particles embedded therein, said magnetic particles have an average size of not more than 1,000 Angstroms.

3. The method according to claim 1 wherein said predetermined area comprises the heart.

4. The method according to claim 1 wherein said microparticles are injected into the coronary arteries.

5. The method according to claim 1 wherein said microparticles are injected into the peripheral veneous system.

6. The method according to claim 1 wherein, in lieu of said biodegradable microparticles, biocompatable microparticles are used.

7. A method of ultrasonic imaging for use in medical procedures, comprising the steps of:

(a) subjecting a biocompatible liquid to high frequency energy in the range of about 5,000 to 30,000 Hz so as to produce microbubbles having substantially uniform diameter;

(b) injecting said microbubbles into a mammal to thereby alter the acoustic properties of a predetermined area; and

(c) ultrasonically scanning an area including said predetermined area so as to obtain an enhanced image of said predetermined area.

8. The method according to claim 7 wherein said microbubbles have a mean particle size of about 6 to 20 microns.

9. The method according to claim 7 wherein said liquid is subjected to high frequency energy of about 20,000 Hz.

10. The method of claim 7 wherein said biocompatible liquid is a viscous solution.

11. The method of claim 10 wherein said viscous solution is selected from the group consisting of dextrose, sorbitol, relatively nontoxic radio-opaque dye, and mixtures thereof.

12. The method of claim 11 further comprising saline as a diluent.

13. The method of claim 10 wherein said viscous solution is a mixture of relatively non-toxic radio-opaque dye and sodium chloride.

14. The method of claim 7 wherein the step of subjecting said biocompatible liquid to high frequency energy results in cavitation bubbles and said cavitation bubbles collapse resulting in by-product bubbles having substantially uniform diameter.

15. A method of ultrasonic imaging for use in medical procedures, comprising the steps of:

(a) forming biocompatible microparticles comprising amino acid polymer matrix containing at least one ultrasound image enhancing material selected from the group consisting of air, glass, graphite, nitrogen, carbon dioxide, metal flakes, magnetite, magnetic iron oxides and carbonyl iron;

(b) injecting said microparticles into a mammal to thereby alter the acoustic properties of a predetermined area; and

(c) ultrasonically scanning said predetermined area to obtain an ultrasound scanning image thereof.

16. A method of ultrasound imaging for use in medical procedures, comprising the steps of:

(a) subjecting a biocompatible liquid to high frequency ultrasound energy in the range of about 5,000 to 30,000 Hz thereby producing stable microbubbles having substantially uniform diameters in the range of 6 to 20 microns;

(b) injecting said microbubbles into a mammal to thereby alter the acoustic properties of a predetermined area thereof; and

(c) ultrasonically scanning an area including said predetermined area so as to obtain an enhanced image of said predetermined area.

17. A method of ultrasound imaging for use in medical

19. The method of claim 17 wherein said biocompatible liquid is selected from the group consisting of 70% dextrose, 50% dextrose, 70% sorbitol, a non-toxic radio-opaque dye, and mixtures thereof.

20. The method of claim 17 wherein said biocompatible liquid further comprises saline.

18. Procedures comprising the steps of:

(a) providing a biocompatible liquid selected from the group consisting of dextrose, sorbitol, relatively non-toxic radio-opaque dye and mixtures thereof;

(b) subjecting said biocompatible liquid to ultrasound energy in the range of 5,000 to 30,000 Hz thereby producing stable microbubbles having substantially uniform diameters in the range of 6 to 20 microns;

(c) injecting said microbubbles into a mammal to thereby alter the acoustic properties of a predetermined area of said mammal; and

(d) ultrasonically scanning said mammal including said predetermined area thereby obtaining enhanced images of said predetermined area.