Selective material projection imaging system using nuclear magnetic resonance

• US 4,577,152 A
• Filed: 04/11/1983
• Issued: 03/18/1986
• Est. Priority Date: 04/11/1983
• Status: Expired due to Fees

• Current Assignee: Albert Macovski
• Original Assignee: Albert Macovski
• Inventors: Macovski, Albert
• Primary Examiner(s): Tokar, Michael J.
• Application Number:
  US06/483,827
• Time in Patent Office: 1,072 Days
• Field of Search: 324/300, 324/307, 324/309, 324/312, 324/313
• US Class Current: 324/309
• CPC Class Codes: G01R 33/445 MR involving a non-standard magnetic field B0, e.g. of low magnitude as in the earth's magnetic field or in nanoTesla spectroscopy, comprising a polarizing magnetic field for pre-polarisation, B0 with a temporal variation of its magnitude or direction such as field cycling of B0 or rotation of the direction of B0, or spatially inhomogeneous B0 like in fringe-field MR or in stray-field imaging
• CPC Class Codes: G01R 33/50 based on the determination of relaxation times , e.g. T1 measurement by IR sequences; T2 measurement by multiple-echo sequences
• CPC Class Codes: G01R 33/561 by reduction of the scanning time, i.e. fast acquiring systems, e.g. using echo-planar pulse sequences

Abstract

Two-dimensional projection measurements are formed of the NMR activity within a volume. Measurements are made using different intensities of the main magnetic field, using the different dependencies of relaxation times on magnetic field. The projection measurements are combined to obtain projection images of specific materials within the volume. Projection images are obtained of specific regions within the volume by insuring that the unwanted regions remain insensitized. For improved SNR, projection measurements are repeated to obtain spin-echo signals. The measurements of relaxation times are interleaved so that the data acquisition can occur rapidly.

Claims

1. In a method for producing selective material projection images of a volume using nuclear magnetic resonance the steps of:

measuring the two-dimensional projection of a plurality of components of the nuclear magnetic resonance activity using different intensities of the main magnetic field; and

processing these components to produce one or more two-dimensional projection images of specific materials of the volume.

2. The method as described in claim 1 wherein the step of measuring components includes the step of confining the measurements to a region of the volume.

3. The method as described in claim 1 including the step of re-exciting each measurement region one or more times using inversion excitations to obtain successive spin-echo signals.

4. In a method for making a projection image of selected regions of a volume using nuclear magnetic resonance the steps of

initially insensitizing non-selected regions of the volume;

forming a series of projection measurements of the selected regions of the volume;

further insensitizing the non-selected regions of the volume between each projection measurement; and

reconstructing the projection image of the selected regions of the volume using the series of projection measurements.

5. The method as described in claim 4 wherein the step of initially insensitizing non-selected regions of the volume includes the step of saturating the spins of the non-selected regions.

6. The method as described in claim 4 wherein the step of initially insensitizing non-selected regions of the volume includes the step of exciting the non-selected regions with a field which provides a flip angle of substantially 90°

.

7. The method as described in claim 4 wherein the step of further insensitizing the non-selected regions of the volume between each projection measurement includes the step of exciting the non-selected regions with a field which provides a flip angle of substantially 90°

.

8. The method as described in claim 4 wherein the step of further insensitizing the non-selected regions of the volume between each projection measurement includes the step of exciting the non-selected regions with a field which provides a flip angle of greater than 90°

such that the non-selected region will not produce a signal when the projection measurements are made of the selected region.

9. In a method for producing a projection image of a volume using nuclear magnetic resonance the steps of:

measuring the projections of the volume;

repeating the projection measurements using inverting excitations to produce spin-echo signals;

combining the received signals derived from each set of corresponding projection measurements to produce enhanced projection measurements; and

processing the enhanced projection measurements to provide the projection image of the volume whereby the signal-to-noise ratio has been enhanced.

10. The method as described in claim 9 wherein the step of measuring the projections of the volume includes the step of measuring a plurality of components of the nuclear magnetic resonance activity and the step of processing the enhanced projection measurements includes the step of combining the measurements of different components to provide projection images of specific materials of the volume.

11. The method as described in claim 9 wherein the step of measuring projections of the volume includes the step of confining the measurements to a region of the volume.

12. In a method for making a projection image of a volume which is sensitive to the nuclear magnetic resonance relaxation time the steps of:

exciting a first planar section in the volume using two excitation signals;

receiving signals from the first excited planar section following a relaxation interval;

similarly exciting other planar sections in the volume parallel to the first planar section such that the first of the excitations occurs before the signals are received from the first planar section; and

processing the received signals to provide a projection image sensitive to the relaxation time.

13. The method as described in claim 12 including the step of combining the received signals with signals representing different components of the nuclear magnetic resonance activity and the step of processing the combined signals to provide projection images of specific materials of the volume.

14. The method as described in claim 12 wherein the step of receiving signals from the planar section of the volume includes the step of confining the measurements to a region of the volume.

15. The method as described in claim 12 including the step of providing repeated excitation of each planar section using inversion excitations to obtain spin-echo signals and where the step of processing includes the step of combining the signals from each planar section.

16. The method as described in claim 12 where the step of exciting the planar sections using two excitation signals includes the steps of exciting the entire volume simultaneously with one of the excitation signals and exciting each planar section sequentially with the other excitation signal.

17. The method as described in claim 12 where the step of exciting the planar sections using two excitation signals includes the step of exciting each planar section with two excitation signals which are separated by the same time interval.

18. Apparatus for providing selective material projection images of a volume using nuclear magnetic resonance comprising:

means for measuring the two-dimensional projection of components of the nuclear magnetic resonance activity using different intensities of the main magnetic field; and

means for processing these components to produce one or more two-dimensional projection images of specific materials in the volume.

19. Apparatus as described in claim 18 including means for restricting the projection measurements to a region of the volume.

20. Apparatus as described in claim 18 including means for providing repeated measurements using inversion excitations to obtain spin-echo signals and further including means for combining corresponding measurements.

21. Apparatus for making projection images of selected regions of a volume using nuclear magnetic resonance comprising:

means for initially insensitizing non-selected regions of the volume;

means for deriving a sequence of projection measurements of selected regions of the volume;

means for further insensitizing the non-selected regions of the volume between each projection measurement; and

means for processing the projection measurements to produce the projection image of selected regions of the volume.

22. Apparatus as recited in claim 21 wherein the means for initially insensitizing non-selected regions of the volume includes means for saturating the spins of the non-selected regions.

23. Apparatus as recited in claim 21 wherein the means for initially insensitizing non-selected regions of the volume includes means for exciting the non-selected regions with an rf field which provides a flip angle of substantially 90°

.

24. Apparatus as described in claim 21 wherein the means for further insensitizing the non-selected regions of the volume between projection measurements includes means for exciting the non-selected regions with an rf field which provides a flip angle of substantially 90°

.

25. Apparatus as described in claim 21 wherein the means for further insensitizing the non-selected regions of the volume between projection measurements includes means for exciting the non-selected region with an rf field to provide a flip angle sufficiently greater than 90°

such that the non-selected region will not produce a signal during the subsequent measuring interval.

26. Apparatus as recited in claim 21 wherein the selected region of the volume is a planar section and the non-selected region is the entire volume except for the planar section and the projection direction is normal to the planar section whereby the projection image is a cross-sectional image.

27. Apparatus for producing a projection image of a volume using nuclear magnetic resonance comprising:

means for making projection measurements of the volume;

means for repeating projection measurements using inversion excitations to produce spin-echo signals;

means for combining the signals from corresponding projection measurements to produce enhanced projection measurements; and

means for processing the enhanced projection measurements to produce a projection image of the volume.

28. Apparatus as described in claim 27 wherein the means for making projection measurements include means for measuring a plurality of components of the nuclear magnetic resonance activity and the means for processing the enhanced projection measurements includes means for combining the measurements of the different components to provide projection images of specific materials of the volume.

29. Apparatus as described in claim 27 wherein the means for making projection measurements include means for confining the measurements to a selected region of the volume.

30. Apparatus for producing a projection image of a volume which is sensitive to the nuclear magnetic relaxation time comprising:

means for exciting a first planar section of the volume using two excitation signals;

means for receiving signals from the first excited planar section following a relaxation interval;

means for similarly exciting other planar sections in the volume parallel to the first planar section such that the first of the excitations occurs before signals are received from the first section; and

means for processing the received signals to provide a projection image sensitive to the relaxation time.

31. Apparatus as recited in claim 30 including means for combining the received signals with other signals representing different components of the nuclear magnetic resonance activity and means for processing these to provide projection images of specific materials of the volume.

32. Apparatus as described in claim 30 wherein the means for receiving signals from the planar section includes means for confining the measurements to a region of the volume.

33. Apparatus as recited in claim 30 including means for providing repeated excitation of each planar section using inversion excitations to obtain spin-echo signals and the processing means includes means for combining the signals from each planar section.

34. Apparatus as recited in claim 30 wherein the means for exciting the planar sections using two excitation signals includes means for exciting the entire volume simultaneously with one of the excitation signals and means for exciting each planar section sequentially with the other excitation signal.

35. Apparatus as recited in claim 30 wherein the two excitation signals for each planar section are separated by the same time interval.

36. Apparatus as recited in claim 30 wherein the relaxation process is the spin-lattice relaxation time T₁ and the first excitation is an inversion excitation and the second excitation involves a flip angle of substantially 90°

.

37. Apparatus as recited in claim 30 wherein the relaxation process is the spin-spin relaxation time T₂ and the first excitation involves a flip angle of substantially 90°

and the second excitation is an inversion excitation.