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Bio-artificial ultrafiltration pancreas

  • US 4,578,191 A
  • Filed: 08/01/1983
  • Issued: 03/25/1986
  • Est. Priority Date: 08/09/1982
  • Status: Expired due to Fees
First Claim
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1. A bio-artificial pancreas comprising:

  • two ultrafiltration membranes having approximately parallel substantially planar confronting surfaces spaced apart a distance such that the space there between defines a volume of small thickness;

    islets of Langerhans contained in said compartment;

    means defining a blood path whereby blood flowing along said blood path successively sweeps said surfaces of said two membranes opposite said volume occupied by said islets of Langerhans over a length greater by at least one order of magnitude than the distance which separates said membranes;

    said membranes being constructed and arranged such that said volume fulfills the condition;

    
    
    space="preserve" listing-type="equation">V.sub.i ≦

    (S)(P.sub.M)(τ

    )(Δ

    P/8) in whichVi =said volume,S=total membrane area,PM =hydraulic permeability of membrane,τ

    =acceptable time constant, andΔ

    P=available drive pressure.

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