Bio-artificial ultrafiltration pancreas
First Claim
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1. A bio-artificial pancreas comprising:
- two ultrafiltration membranes having approximately parallel substantially planar confronting surfaces spaced apart a distance such that the space there between defines a volume of small thickness;
islets of Langerhans contained in said compartment;
means defining a blood path whereby blood flowing along said blood path successively sweeps said surfaces of said two membranes opposite said volume occupied by said islets of Langerhans over a length greater by at least one order of magnitude than the distance which separates said membranes;
said membranes being constructed and arranged such that said volume fulfills the condition;
space="preserve" listing-type="equation">V.sub.i ≦
(S)(P.sub.M)(τ
)(Δ
P/8) in whichVi =said volume,S=total membrane area,PM =hydraulic permeability of membrane,τ
=acceptable time constant, andΔ
P=available drive pressure.
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Abstract
The bio-artifical pancreas comprises islands of Langerhans contained in a volume defined by two approximately parallel ultrafiltration membranes, able to be formed by two successive portions of the same flat membrane or the same hollow fiber. The surfaces of the membrane opposite the volume occupied by the islands are successively swept by the same blood stream over a length greater by at least one order of size than the distance separating the membranes.
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Citations
10 Claims
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1. A bio-artificial pancreas comprising:
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two ultrafiltration membranes having approximately parallel substantially planar confronting surfaces spaced apart a distance such that the space there between defines a volume of small thickness; islets of Langerhans contained in said compartment; means defining a blood path whereby blood flowing along said blood path successively sweeps said surfaces of said two membranes opposite said volume occupied by said islets of Langerhans over a length greater by at least one order of magnitude than the distance which separates said membranes; said membranes being constructed and arranged such that said volume fulfills the condition;
space="preserve" listing-type="equation">V.sub.i ≦
(S)(P.sub.M)(τ
)(Δ
P/8)in which Vi =said volume, S=total membrane area, PM =hydraulic permeability of membrane, τ
=acceptable time constant, andΔ
P=available drive pressure. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification