Infection-resistant materials and method of making same through use of sulfonamides

• US 4,581,028 A
• Filed: 04/30/1984
• Issued: 04/08/1986
• Est. Priority Date: 04/30/1984
• Status: Expired due to Term

• Current Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Original Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Inventors: Modak, Shanta, Fox, Charles L. Jr., Reemtsma, Keith
• Primary Examiner(s): GRIFFIN, RONALD
• Application Number:
  US06/605,793
• Time in Patent Office: 708 Days
• Field of Search: 424/27, 424/229, 424/95, 8/94.11, 435/1, 128/335.5, 128/127, 128/926, 604/265, 604/285, 3/1.4, 3/1.5, 3/1.9, 3/1.91
• US Class Current: 623/2.42
• CPC Class Codes: A61B 17/34 Trocars; Puncturing needles pointed biopsy instruments A61B10/0233; devices for piercing the ear-lobes A44C7/001; seals or hemostasis valves A61M39/06
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2/24 Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30 Joints
• CPC Class Codes: A61L 17/005 containing a biologically active substance, e.g. a medicament or a biocide
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: Y10S 977/753 with polymeric or organic binder

Abstract

Infection-resistant materials, and methods of preparing same, suitable for use within the interior of a human or animal body in such forms as vascular grafts prostheses, or other implanted devices. The material is rendered infection-resistant by incorporating therein antimicrobial agents, such as metal salts of sulfonamides and other antimicrobials or antibacterials, such as piperacillin. In particular illustrative embodiments, silver sulfadiazine is complexed by novel techniques with natural or synthetic polymeric materials such as silk, polyester (e.g., Dacron), polyurethane, polytetrafluoroethylene, or silicone-based material, to provide long-term prevention of infections which may otherwise result during, or after, surgery or implantation of a device.

Claims

1. A method for reducing the risk of infection by bacteria as a result of prosthetic vascular graft surgery, said method comprising the use of a vascular graft comprising a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamdies.

2. A method for reducing the risk of infection by bacteria as a result of a device implanted within the interior of a human animal body, said method comprising the use of an implanted device which comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides for at least a portion of the implanted device.

3. An infection-resistant device which is a vascular graft prosthesis for use within the interior of a human or animal body wherein at least a portion of said vascular graft prosthesis comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.

4. An infection-resistant device which is a catheter for use within the interior of a human or animal body wherein at least a portion of said catheter comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.

5. An infection-resistant device which is an internal contraceptive device for use within the interior of a human or animal body wherein at least a portion of said internal contraceptive device comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.

6. An infection-resistant device which is an internal feminine hygiene device for use within the interior of a human or animal body wherein at least a portion of said internal feminine hygiene device comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.

7. An infection-resistant device which is a surgical suture for use within the interior of a human or animal body wherein at least a portion of said surgical suture comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.

8. An infection-resistant device which is a vaginal sponge for use within the interior of a human or animal body wherein at least a portion of said vaginal sponge comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.

9. An infection-resistant device which is a heart valve for use within the interior of a human or animal body wherein at least a portion of said heart valve comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.

10. An infection-resistant device which is a cannula for use within the interior of a human or animal body wherein at least a portion of said cannular comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.

13. The infection-resistant device of any one of claims 3-12 wherein said polymeric substrate comprises synthetic polymeric material.

14. The infection-resistant device of claim 13 wherein said synthetic polymeric material is selected from the group consisting of polyester, polytetrafluoroethylene, polyurethane and polyamide.

15. The infection-resistant device of claim 14 wherein said synthetic polymeric material is a polyester.

16. The infection-resistant device of claim 13 wherein said synthetic polymeric material is silicone.

17. The infection-resistant device of any one of claim 3-12 wherein said polymeric substrate comprises a natural polymeric material.

18. The infection-resistant device of claim 17 wherein said natural polymeric material is selected from the group consisting of collagenous substances, biological tissues and silk.

19. The infection-resistant device of any one of claims 3-12 wherein said at least one antimicrobial agent comprises a silver salt of a sulfonamide.

20. The infection-resistant device of claim 19 wherein said at least one antimicrobial agent comprises silver sulfadiazine.

21. The infection-resistant device of claim 20 wherein said at least one antimicrobial agent further includes an antibacterial agent.

22. The infection-resistant device of claim 21 wherein said at least one antibacterial agent is sodium piperacillin.

11. An infection-resistant device which is a cosmetic implant for use within the interior of a human or animal body wherein at least a portion of said cosmetic implant comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.

12. An infection-resistant device which is a bone or joint replacement for use within the interior of a human or animal body wherein at least a portion of said bone or joint replacement comprises a polymeric substrate provided with an effective amount of at least one antimicrobial agent selected from the group consisting of metal salts of sulfonamides.