Dialysis material and method for removing uremic substances

• US 4,581,141 A
• Filed: 04/05/1983
• Issued: 04/08/1986
• Est. Priority Date: 02/27/1978
• Status: Expired due to Fees

• Current Assignee: HemoCleanse, Inc.
• Original Assignee: Purdue Research Foundation (The Trustees of Purdue University (d/b/a Purdue University))
• Inventors: Ash, Stephen R.
• Primary Examiner(s): Spear, Frank
• Application Number:
  US06/482,210
• Time in Patent Office: 1,099 Days
• Field of Search: 210/687, 210/648, 210/698, 210/321.1, 210/321.2, 210/321.3, 210/502, 252/180, 252/308, 252/316, 423/328, 423/327, 423/329
• US Class Current: 210/502.1
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/26 and internal elements which are moving
• CPC Class Codes: A61M 1/287 Dialysates therefor
• CPC Class Codes: A61M 1/3687 Chemical treatment A61M1/3675 takes precedence
• CPC Class Codes: B01D 2311/06 Specific process operations in the permeate stream
• CPC Class Codes: B01D 2311/2626 Absorption or adsorption
• CPC Class Codes: B01D 61/30 Accessories; Auxiliary operation

Abstract

Compositions for removing uremic substances during hemodialysis comprising an aqueous slurry containing charcoal, a highly calcium-loaded zeolite cation exchanger, purified urease (which may be bound to a portion of the zeolite, a suspending agent, and optionally an aliphatic carboxylic acid resin in the H⁺ form, and a hemodialysis method employing such compositions.

Claims

1. A composition for use in dialysis comprising a surface adsorptive substance capable of adsorption of uremic substances, water, a suspending agent, urease, a calcium-loaded cation exchanger, an aliphatic carboxylic acid resin in the H⁺ form, and a metabolizable organic acid buffer.

2. A composition according to claim 1 in which the metabolizable organic acid is diethylmalonic acid.

3. A composition according to claim 1 in which the aliphatic carboxylic acid resin is polymerized methacrylic acid cross-linked with divinylbenzene.

4. A composition according to claim 1 in which the cation exchanger is a calcium-loaded zeolite.

5. The composition of claim 4 in which the zeolite is about 50% calcium loaded.

6. A composition according to claim 1 in which the cation exchanger is a mixture of zeolites capable of furnishing from 2.8-3.2 meq. of calcium ions per gram.

7. A composition according to claim 1 in which the suspending agent is methylcellulose.

8. A composition according to claim 1 in which the surface adsorptive substance is activated charcoal.

9. A composition according to claim 1 in which the total weight of solids in the suspension is not more than 3 g/l.

10. A composition according to claim 1 in which the cation exchanger is a zeolite or mixture of zeolites and the urease is bound to a portion of one of the zeolites.