Method for continuously measuring a specified ingredient in a diluted liquid

• US 4,585,007 A
• Filed: 05/10/1983
• Issued: 04/29/1986
• Est. Priority Date: 05/15/1982
• Status: Expired due to Fees

• Current Assignee: Kabushiki Kaisha Kaisha Kyoto Daiichi Kagaku
• Original Assignee: Kabushiki Kaisha Kyoto Daiichi Kagaku
• Inventors: Hyodo, Hiroshi, Uchigaki, Takatoshi, Iwase, Teijiro
• Primary Examiner(s): Coven, Edward M.
• Application Number:
  US06/493,415
• Time in Patent Office: 1,085 Days
• Field of Search: 128/632
• US Class Current: 600/363
• CPC Class Codes: A61M 1/3672 Means preventing coagulation

Abstract

A method for accurately performing concentration measurements while compensating the dilution ratio as needed during continuous measurement of specified ingredient in the liquid to be tested. The liquid to be tested is diluted by a diluent, wherein the liquid to be tested and the diluent or the mixture of the two and the diluent is transferred by means of the respective tube pumps to a measuring section. Either or both of the quantities of liquid-feeding of those two liquids are changed at the beginning of measuring or in an optional stage during the time of the measurement, diluted and mixed at two or more dilution ratios. Then the real dilution ratio at the time of changing the quantities of the said liquids is found on the basis of the measured value of the substance to be measured at the respective dilution ratios, and the concentration of the substance contained in the liquid to be tested is determined by using the real dilution ratio.

Claims

1. A method for continuously measuring a specified ingredient of a first liquid, said first liquid being diluted with a diluent to form a diluted liquid, while continuously monitoring the concentration of said specified ingredient contained in said first liquid by selecting and mixing said first liquid and said diluent and transferring at least one of said diluted liquid, said diluent and said first liquid by respective tube pumps into a measuring section wherein dilution ratios are determined, said method comprising the steps of:

selecting said diluted liquid at two or more dilution ratios and changing the quantity of at least one of said transferred diluent and said transferred first liquid during said determination in said measuring section to change at least one of said dilution ratios;

determining a real dilution ratio of said diluted liquid at a first period of time, said first period of time occurring when quantities of said transferred liquids have been changed, according to measured values of said specified ingredients determined at said dilution ratios; and

determining the concentration of said specified ingredient in said first liquid using said real dilution ratios obtained in any one of periods of time occurring before, after and during said first period of time.

2. The method according to claim 1 further comprising the steps of comparing said real dilution ratio obtained by changing said quantity of transferred liquid having a predetermined dilution ratio δ

₀ wherein δ

₀ is obtained by using an initial reference liquid at the beginning of the measurement, and further compensating said changed liquid so as to return to the original dilution ratio by adjusting said quantity of one of said transferred first liquid and said transferred diluent.

3. The method according to claims 1 or 2 wherein said first liquid is blood and said diluent is an anticoagulant for diluting said blood, said method further including the step of inserting a double current catheter into a patent, said blood being drawn from said patient and mixed with said anticoagulant via said double current catheter.

4. The method according to claim 3 wherein said double current catheter includes individual catheter tubes for carrying said diluent and said blood each of said tubes being coupled directly to said tube pumps.