Electrochemical controlled release drug delivery system
First Claim
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1. A method for the controlled delivery of an ionic bioactive chemical into a physiological medium comprising:
- (a) ionically binding said chemical to a polymeric body comprising oppositely-charged redox sites;
(b) contacting said polymeric body with said physiological medium; and
(c) releasing said bound chemical into said medium as an ionic species by neutralizing the charge on the polymeric body.
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Abstract
A method is disclosed for the controlled delivery of an ionic bioactive chemical into a physiological medium comprising ionically binding the chemical to redox sites on a charged polymer and releasing the bound chemical into the medium by neutralizing the charge on the polymer.
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Citations
19 Claims
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1. A method for the controlled delivery of an ionic bioactive chemical into a physiological medium comprising:
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(a) ionically binding said chemical to a polymeric body comprising oppositely-charged redox sites; (b) contacting said polymeric body with said physiological medium; and (c) releasing said bound chemical into said medium as an ionic species by neutralizing the charge on the polymeric body. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A system for the controlled release of a bioactive ionic chemical into a physiological medium comprising:
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(a) a working electrode comprising a charged conductive polymer; (b) a bioactive ionic chemical ionically bound to said electrode; and (c) means comprising a power supply of reversible polarity which is capable of charging or discharging said polymer by delivering an anodic or cathodic current thereto. - View Dependent Claims (15, 16, 17, 18, 19)
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Specification