Electrochemical controlled release drug delivery system

• US 4,585,652 A
• Filed: 11/19/1984
• Issued: 04/29/1986
• Est. Priority Date: 11/19/1984
• Status: Expired due to Fees

• Current Assignee: Regents of The University of Minnesota (University of Minnesota)
• Original Assignee: Regents of The University of Minnesota (University of Minnesota)
• Inventors: Miller, Larry L., Blankespoor, Ronald L., Zinger, Baruch
• Primary Examiner(s): Niebling, John F.
• Assistant Examiner(s): Chapman, Terryence
• Application Number:
  US06/673,522
• Time in Patent Office: 526 Days
• Field of Search: 128/1 R, 128/783, 128/784, 204/180.1, 204/228, 204/301, 424/14, 424/16, 424/19, 424/25, 424/DIG. 6, 424/DIG. 7, 424/83, 604/890, 604/891
• US Class Current: 604/891.1
• CPC Class Codes: A61K 47/559 Redox delivery systems, e.g. dihydropyridine pyridinium salt redox systems
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: Y10S 424/07 Microporous membranes

Abstract

A method is disclosed for the controlled delivery of an ionic bioactive chemical into a physiological medium comprising ionically binding the chemical to redox sites on a charged polymer and releasing the bound chemical into the medium by neutralizing the charge on the polymer.

Claims

1. A method for the controlled delivery of an ionic bioactive chemical into a physiological medium comprising:

(a) ionically binding said chemical to a polymeric body comprising oppositely-charged redox sites;

(b) contacting said polymeric body with said physiological medium; and

(c) releasing said bound chemical into said medium as an ionic species by neutralizing the charge on the polymeric body.

2. The method of claim 1 wherein said polymeric body is conductive.

3. The method of claim 2 wherein the charged polymeric body comprises cationic sites and is employed to bind anionic chemicals which are released by employing a cathodic current to neutralize the charge on the polymeric body.

4. The method of claim 3 wherein the charged polymeric body comprises oxidized polypyrrole or oxidized poly(beta-methoxythiophene).

5. The method of claim 2 wherein the charged polymeric body comprises anionic sites and is employed to bind cationic chemicals which are released by employing an anodic current to neutralize the charge on the polymeric body.

6. The method of claim 5 wherein the charged polymeric body comprises a reduced polyacetylene or a reduced, modified polyquinone.

7. The method of claim 1 wherein an electrode comprising said polymeric body is employed to bind said chemical by charging said electrode in contact with a solution of said ionic chemical.

8. The method of claim 7 wherein the ionic chemical is intermittently released by neutralizing the charge on the polymeric body with a plurality of quantified pulses of current.

9. The method of claim 8 wherein said bound chemicals are released in vivo.

10. The method of claim 9 wherein said electrode is implanted in a patient'"'"'s body cavity or attached to the patient'"'"'s skin.

11. The method of claim 1 wherein said ionic bioactive chemical is the anion of a pharmaceutically-acceptable salt selected from the group consisting of phosphate, sulfate, bisulfite, carboxylate and acidic N--H group salts.

12. The method of claim 1 wherein said ionic bioactive chemical comprises a quaternary ammonium cation.

13. The method of claim 12 wherein said ionic bioactive chemical is the cation of a pharmaceutically-acceptable salt selected from the group consisting of thiazinium, pyridinium, pyrrolidinium, thiazolium and piperidinium salts.

14. A system for the controlled release of a bioactive ionic chemical into a physiological medium comprising:

(a) a working electrode comprising a charged conductive polymer;

(b) a bioactive ionic chemical ionically bound to said electrode; and

(c) means comprising a power supply of reversible polarity which is capable of charging or discharging said polymer by delivering an anodic or cathodic current thereto.

15. The system of claim 14 wherein said electrode comprises a coating of said conductive polymer on an inert, conductive substrate.

16. The system of claim 14 wherein the electrode consists essentially of said conductive polymer.

17. The system of claim 14 wherein said polymer comprises a continuous, conjugated pi-electron network.

18. The system of claim 14 further comprising a variable resistor between said current supply means and said electrode effective to control the magnitude of the current.

19. The system of claim 14 wherein said current supply means comprises an electrode having sufficient electrochemical potential with respect to the working electrode to discharge the charged working electrode when both electrodes are contacted with a physiological medium.