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Cyclic and bridged cyclic somatostatin analogs useful as local anti-inflammatory agents

  • US 4,585,755 A
  • Filed: 04/29/1985
  • Issued: 04/29/1986
  • Est. Priority Date: 04/29/1985
  • Status: Expired due to Fees
First Claim
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1. A method of locally treating inflammatory and allergic conditions comprising applying to the area to be treated an anti-inflammatory and anti-allergically effective amount of a compound having the Formulae:

  • ##STR4## wherein in each of the compounds of Formulae I, II and III;

    W is S or (CH2)n wherein n is 0, 1, or 2;

    X and Z are S or CH2 provided that at least one of X or Z is S;

    Y is S or (CH2)m wherein m is 0, 1 or 2 such that the sulfur may be in any position along the chain;

    R1 and R2 are independently loweralkyl, benzyl, substituted benzyl where the substituent may be one or two of loweralkyl, halogen, hydroxy, amino, nitro or loweralkoxy; and

    loweralkyl substituted with a 5- or 6-membered heterocyclic ring;

    R3 is 3-indolylmethyl or substituted 3-indolylmethyl wherein the substituent may be loweralkyl, loweralkoxy, or halogen;

    R4 is loweralkyl, hydroxyloweralkyl, benzyl, carboxyloweralkyl, aminoloweralkyl or substituted benzyl wherein the substituent may be loweralkyl, loweralkoxy, hydroxy, halogen, amino or nitro; and

    R5 is loweralkyl, benzyl, or substituted benzyl wherein the substituent is loweralkyl, loweralkoxy, hydroxy, halogen amino or nitro.

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