Cosmetic and pharmaceutical sheet material containing polypeptides

• US 4,585,797 A
• Filed: 05/16/1984
• Issued: 04/29/1986
• Est. Priority Date: 04/13/1981
• Status: Expired due to Fees

• Current Assignee: Seton Company (Brady Corporation)
• Original Assignee: Seton Company (Brady Corporation)
• Inventors: Cioca, Gheorghe
• Primary Examiner(s): GRIFFIN, RONALD
• Application Number:
  US06/610,621
• Time in Patent Office: 713 Days
• Field of Search: 424/28, 424/36, 604/289, 604/303, 604/304, 523/105, 523/111, 524/17, 524/20, 524/22, 514/773
• US Class Current: 514/773
• CPC Class Codes: A61K 8/0212 Face masks
• CPC Class Codes: A61K 8/65 Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
• CPC Class Codes: A61L 15/24 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof A61L15/225 takes precedence
• CPC Class Codes: A61L 15/32 Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin A61L15/225 takes precedence
• CPC Class Codes: A61L 26/0014 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 26/0047 Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
• CPC Class Codes: A61L 26/0076 Sprayable compositions
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: C08L 29/04 Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids

Abstract

A flexible continuous film is comprised of a physical admixture of a polypeptide, a plasticizer and a film-forming flexible polymer. When the film is moistened, the polypeptides exude therefrom.

Claims

1. A flexible continuous film comprising a homogeneous physical admixture of:

a polypeptide selected from the group consisting of collagen, elastin and polypeptides derived from collagen and elastin and having a molecular weight of at least 2,000 to 20,000, wherein when said polypeptide is derived from collagen and elastin it is present at a level of 25 to 75 percent by weight based on the weight of the admixture and when said polypeptide is collagen or elastin it is present at a level of 3 to 5 percent by weight based on the weight of said admixture;

20 to 40 percent by weight of a water soluble non-volatile plasticizer having a boiling point in excess of about 150°

C.; and

10 to 20 percent by weight of a film-forming polyvinyl alcohol which is soluble in hot water and insoluble in cold water;

said film, when moistened, will exude said polypeptide while remaining as a continuous film.

2. The flexible continuous film of claim 1 wherein said polypeptide is selected from the group consisting of collagen and polypeptides derived from collagen.

3. The flexible continuous film of claim 1 wherein when said film-forming polypeptide is derived from collagen and elastin it is present at a level of 40 to 60 percent by weight.

4. The flexible continuous film of claim 1 wherein said plasticizer is present at a level of 30 to 40 percent by weight.

5. The flexible continuous film of claim 1 wherein said plasticizer is glycerol.

6. The flexible continuous film of claim 1 mounted on a backing.

7. The flexible continuous film of claim 6 wherein said backing is fabric.

8. The flexible continuous film of claim 7 wherein said backing is nonwoven.