Dosimetry system for strontium-rubidium infusion pump

• US 4,585,941 A
• Filed: 02/28/1983
• Issued: 04/29/1986
• Est. Priority Date: 02/28/1983
• Status: Expired due to Term

• Current Assignee: Bracco International B.V. (Bracco SPA)
• Original Assignee: E R Squibb & Sons Incorporated
• Inventors: Bergner, Brian C.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): Falk, Steven
• Application Number:
  US06/470,840
• Time in Patent Office: 1,156 Days
• Field of Search: 128/655, 128/654, 128/665, 128/653, 128/659, 250/362, 250/363 S, 250/363 SR, 313/532, 313/534, 604/65, 604/67
• US Class Current: 250/363.02
• CPC Class Codes: A61M 2205/051 with radiation therapy
• CPC Class Codes: A61M 5/007 for contrast media
• CPC Class Codes: A61M 5/1407 Infusion of two or more substances
• CPC Class Codes: A61M 5/1452 pressurised by means of pistons
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: G01T 1/203 the detector being made of plastics
• CPC Class Codes: G21G 1/0005 Isotope delivery systems use of radioisotopes as tracers G21H5/02

Abstract

The dosimetry system used with a strontium-rubidium infusion system is a very high speed circuit capable of measuring the radioactive dosage infused into a patient in real time. The dosimetry system is capable of receiving very short duration input pulses generated by a photomultiplier tube in response to the presence of radioactivity.

Claims

1. A dosimetry system for a strontium-rubidium generator comprising:

(a) a photomultiplier tube, having a face through which input signals in the form of light are received;

(b) a plastic scintillator mounted on said face;

(c) means for reflecting back into said tube any light which scintillates from the plastic scintillator;

(d) means for preventing stray light from striking said plastic scintillator; and

(e) a single channel analyzer electrically connected to said photomultipler tube for receiving pulses from said photomultiplier tube, said single channel analyzer comprising a very high speed comparator which receives input pulses from said photomultipler tube including means for analyzing input pulses having pulse widths of significantly less than 50 nanoseconds.

2. The dosimetry system of claim 1 further comprising means for reducing the pulse repetition rate of said input pulses.

3. The dosimetry system of claim 2 wherein said means for reducing the pulse repetition rate of said input pulses comprises a programmable divide-by-N circuit capable of receiving a very high pulse repetition rate and bringing the pulse repetition rate down into any desirable range.

4. The dosimetry system of claim 3 wherein said means for analyzing input pulses having pulse widths of significantly less than 50 nanoseconds is comprised of a one-shot circuit.

5. The dosimetry system of claim 4 wherein said one-shot circuit is comprised of an emitter coupled logic flip-flop which can accept input pulses having pulse widths of significantly less than 50 nanoseconds.

6. The dosimetry system of claim 1 wherein said means for analyzing generates an output comprising output pulses and further comprising means for converting the output pulses of said means for analyzing into a measure of radioactivity.

7. The dosimetry system of claim 6 wherein said means for converting the output pulses into a measure of radioactivity comprises a Multiplier-Divider circuit which accepts said output pulses and multiplies them by a number corresponding to the eluate Flow Rate divided by a constant, K, in order to carry out the formula:

##EQU5## Where, A=total acitvity (in milliCuries);

N=net counts (from Single Channel Analyzer);

F=Flow Rate; and

K=the calibration factor.