Device for localized heating of biological tissues

• US 4,586,512 A
• Filed: 03/27/1985
• Issued: 05/06/1986
• Est. Priority Date: 06/26/1981
• Status: Expired due to Term

• Current Assignee: Thomson-CSF
• Original Assignee: Thomson-CSF
• Inventors: Hartemann, Pierre, Do-huu, Jean-Paul
• Primary Examiner(s): Coven, Edward M.
• Assistant Examiner(s): Hindenburg, Max F.
• Application Number:
  US06/717,465
• Time in Patent Office: 405 Days
• Field of Search: 128/24 A, 128/303.1, 128/362, 128/399, 128/401, 128/660, 310/334-337, 310/367, 310/369
• US Class Current: 600/447
• CPC Class Codes: A61B 2017/22028 arrays, e.g. phased arrays
• CPC Class Codes: A61B 8/4272 involving the acoustic interface between the transducer and the tissue
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: B06B 1/0625 Annular array

Abstract

A device for therapeutic heating by hyperthermia comprises an emitter which focuses ultrasonic radiation into biological tissues and produces localized heating, especially for the treatment of tumors. The radiation emitter consists of a piezoelectric plate subdivided into annular radiating zones of equal width by a set of concentric circular grooves.

Claims

1. A device for localized heating of biological tissues comprising:

electromechanical transducer means for projecting ultrasonic radiation, coupled to an electric excitation generator having a predetermined oscillation frequency, said transducer means being of the half-wave type and comprising a rigid plate of piezoelectric material, a first face of said plate being provided with a set of concentric annular groves of uniform pitch in the vicinity of the wavelength of said radiation in water, a second face of said plate being smooth and flat,

said plate having annular radiating zones bounded by said grooves and provided with electrodes placed in contact with said faces, each annular radiating zone describing a circle to obtain a circular radiation pattern; and

an electric excitation generator having a predetermined oscillation frequency, said generator including an array of adjustable phase-shifting means for supplying said electrodes at least partially with voltages having adjustable phases for selectively focusing said radiation into biological tissues which are acoustically coupled with said second face, said selective focusing including moving said radiation pattern in a direction orthogonal to said plate.

2. A device according to claim 1, wherein:

said second face is covered by a bag which is permeable to said radiation and filled with a liquid having an acoustic impedance whose value is closely related to the acoustic impedance of water.

3. A device according to claim 1 or claim 2, wherein:

the face of the piezoelectric plate in which grooves are formed is fitted with a cover containing a medium having an acoustic impedance of negligible value compared with the acoustic impedance of said piezoelectric material.

4. A device according to claim 1 or claim 3, wherein the piezoelectric plate is provided at the center of said plate with ultrasonic transducer means in cooperating relation with a visual display system used to monitor the irradiated zone and to control the degree of heating, said visual display means being utilized for emission and reception of ultrasonic radiations having a higher frequency than said predetermined frequency.

5. A device according to claim 1, wherein said annular radiating zones radiate in sectors with phase-shifted electrical excitations which permit transverse scanning of the focused beam.

6. A device according to claim 1, wherein:

the electrical excitation of said annular radiating zones is phase-shifted so as to focus said radiation in a closed circular contour.

7. A device according to claim 1, wherein:

said piezoelectric material is a piezoelectric ceramic material metallized on both faces.

8. A device according to claim 7, wherein:

the ratio of the width of said annular radiating zones to the thickness of said plate is within the range of 0.5 to 1.

9. A device according to claim 1, wherein:

the emission of ultrasonic radiation is continuous emission.

10. A device according to claim 1, wherein:

the emission of ultrasonic radiation is pulsed emission.

11. A localized heating device according to claim 1, wherein the radiating zones of one and the same piezoelectric plate form N emitting groups excited by voltages in which the phases ensure simultaneous projection of N ultrasonic radiations onto N separate and distinct focal points.

12. A device according to claim 11, wherein the phases of said voltages are chosen so as to ensure that at least one of the N ultrasonic radiations is brought to a point focus.

13. A device according to claim 11, wherein the phases of said voltages are chosen so as to ensure that at least one of the N ultrasonic radiations is brought to an annular focus.

14. A device according to claim 11, wherein the frequencies of said ultrasonic radiations are differentiated.

15. A device according to claim 11, wherein the ultrasonic radiations emanate from inter-related radiating annular zones.

16. A device according to claim 11, wherein at least one of the ultrasonic radiations emanates from an emissive area comprising a plurality of contiguous annular zones.

17. A device according to claim 1 wherein said radiation pattern is a point.

18. A device according to claim 1 wherein said selective focusing includes focusing said radiation to substantially a single point in said biological tissues.

19. A device according to claim 1 wherein said selective focusing includes focusing said radiation to substantially a first focal point and a second point in said biological tissues.

20. A device according to claim 19 wherein said first and second focal points are co-linear with a line orthogonal to said plate.

21. A device according to claim 1 wherein said selective focusing includes focusing said radiation at a plurality of focal points in said biological tissues.

22. A device according to claim 1 wherein each said annular radiating zone is divided into a plurality of elementary radiators, each being individually excited by said electric excitation generator, and wherein said selective focusing includes moving said radiation pattern in a direction of substantially parallel to said plate.

23. A device according to claim 1 wherein said selective focusing includes focusing said radiation into a focal point and into a radiation pattern having a closed circular contour.

24. A device according to claim 1 further including:

imagery transducer means, abutting said annular radiating zones, for transmitting radiation to and receiving radiation from said biological tissues and for providing and image signal containing imaging information about said biological tissues; and

imaging means for receiving said image signal and providing an output signal from which an image of said biological tissues is derived.

25. A device according to claim 24 further including display means, coupled to said imaging means, for displaying an image of said biological tissues.

26. A device according to claim 24 wherein said imagery transducer means includes an array of annular imaging radiation zones which are substantially concentric with said annular radiating zones.

27. A device according to claim 26 further including an excitation electrode, arranged substantially concentric with said annular imaging zones, for transmitting ultrasonic radiation into said biological tissues.