Treatment of osteitis

• US 4,587,268 A
• Filed: 03/08/1984
• Issued: 05/06/1986
• Est. Priority Date: 09/03/1980
• Status: Expired due to Term

• Current Assignee: ED. Geistlich Soehne AG Fuer Chemische Industrie
• Original Assignee: ED. Geistlich Soehne AG Fuer Chemische Industrie
• Inventors: Pfirrmann, Rolf W.
• Primary Examiner(s): Kepplinger, Esther M.
• Assistant Examiner(s): Foley, Shawn P.
• Application Number:
  US06/587,707
• Time in Patent Office: 789 Days
• Field of Search: 424/177, 424/37, 424/95, 424/359, 424/36, 424/19, 424/28, 604/891, 260/117, 3/1.9, 514/774, 514/222
• US Class Current: 514/774
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2002/30677 Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 26/0066 Medicaments; Biocides
• CPC Class Codes: A61L 27/3608 Bone, e.g. demineralised bone matrix [DBM], bone powder
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body

Abstract

A composition comprising a resorbable aqueous gel having dissolved or dispersed therein one or more water-soluble medicaments is of use in the treatment of wounds.

Such a composition is of use in a method of healing an infection in a cavity in bone or other tissue whereby the resorbable aqueous gel is placed in the cavity and allowed to remain there until resorbed, the aqueous phase of the gel containing the water soluble medicament.

The medicament is preferably an antibiotic or a methylol transfer antibacterial.

Claims

1. A composition for the treatment of osteitis comprising a flexible solid in granular form adapted to be introduced into a bone cavity, the said solid comprising a resorbable aqueous gel of one or more cross-linked fibrous proteins having dissolved or dispersed therein an antibacterially effective amount of one or more water-soluble antibacterial medicaments.

2. A composition as claimed in claim 1 wherein the gel comprises cross-linked gelatin.

3. A composition as claimed in claim 1 wherein the protein is cross-linked by a methylol-transfer agent.

4. A composition as claimed in claim 3 wherein the methylol transfer agent comprises formaldehyde.

5. A composition as claimed in claim 1 wherein the antibacterial medicament comprises an antibiotic.

6. A composition as claimed in claim 1 wherein the flexible solid is in the form of a granulate in admixture with spongiosa tissue.

7. A composition as claimed in claim 1 wherein the flexible solid is in the form of a rod.

8. A method of treating osteitis which comprises introducing into a bone cavity infected with osteitis a flexible solid as claimed in claim 1 and allowing it to remain there until resorbed.

9. A composition as claimed in claim 1 wherein the antibacterial medicament comprises a methylol-transfer antibacterial agent.