Transdermal administration of fentanyl and device therefor
DCFirst Claim
1. A process for inducing and maintaining analgesia which comprises administering through an area of intact skin, a skin permeable form of a material selected from the group consisting of fentanyl and its analgetically effective derivatives at an analgetically effective rate and continuing the administration of said material at said rate for an extended period of time at least sufficient to induce analgesia.
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Accused Products
Abstract
Transdermal delivery systems for delivery of fentanyl and its analgetically effective derivatives for extended periods of time are disclosed which deliver the base form of the drug at a rate of from 0.5 to 10 μg/cm2 /hr for a substantial portion of their useful life. The systems can be from 5-100 cm2 in releasing surface and preferably employ an in-line amine resistant adhesive. Preferred rate controlled systems utilize an aqueous ethanolic gel to minimize drug content.
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Citations
58 Claims
- 1. A process for inducing and maintaining analgesia which comprises administering through an area of intact skin, a skin permeable form of a material selected from the group consisting of fentanyl and its analgetically effective derivatives at an analgetically effective rate and continuing the administration of said material at said rate for an extended period of time at least sufficient to induce analgesia.
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16. A process for the transdermal administration of a material selected from the group consisting of fentanyl and its analgetically effective derivatives which comprises:
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(a) contacting a predetermined area of intact skin with a source of skin permeable form of said materia1; (b) maintaining said source in material transmitting relationship to said area of intact skin for an administration period of at least 12 hours; and (c) delivering said material into the skin at a rate within the range of about 0.1-10 μ
g/cm2 /hour for at least about 12 hours. - View Dependent Claims (17, 18, 19, 20, 21, 31, 32, 33)
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22. A medical device for the transdermal administration of a material selected from the group consisting of fentanyl and its analgetically effective derivatives at an analgetically effective rate for an extended period of time of at least four hours which comprises:
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(a) reservoir means containing a skin permeable form of said material in an amount sufficient to deliver said material at said analgetically effective rate for said extended period of time and, (b) means for maintaining a said reservoir means in material transmitting relationship to intact skin. - View Dependent Claims (23, 24, 25, 26, 27)
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28. A medical device for continuous transdermal administration of a material selected from the group consisting of fentanyl and its analgetically effective, derivates comprising, in combination:
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(a) a reservoir for said material having a skin proximal, material releasing surface area in the range of about 5-100 cm2, said reservoir containing between 0.1 and 50% by weight of a skin permeable form of said material in amounts and at a concentration adequate to permit delivery of said material through intact human skin at a rate within the range of from 0.5 to 10 μ
g/cm2 /hr for at least about 12 hours and(b) means for maintaining said reservoir in material transmitting relationship to the skin. - View Dependent Claims (29, 30, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58)
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Specification