Hydrophilic pressure sensitive biomedical adhesive composition

• US 4,593,053 A
• Filed: 12/07/1984
• Issued: 06/03/1986
• Est. Priority Date: 12/07/1984
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Cahalan, Patrick T., Holmblad, Carolann M., Jevne, Allan H., Vegoe, Brett R.
• Primary Examiner(s): Griffin, Ronald W.
• Application Number:
  US06/679,653
• Time in Patent Office: 543 Days
• Field of Search: 523/111, 523/105, 524/503, 424/80, 514/944
• US Class Current: 523/111
• CPC Class Codes: A61K 9/7053 obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
• CPC Class Codes: A61L 15/585 Mixtures of macromolecular compounds
• CPC Class Codes: C08L 2666/04 Macromolecular compounds according to groups C08L7/00 - C08L49/00, or C08L55/00 - C08L57/00; Derivatives thereof
• CPC Class Codes: C08L 29/04 Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
• CPC Class Codes: C08L 39/06 Homopolymers or copolymers of N-vinyl-pyrrolidones
• CPC Class Codes: C09J 139/06 Homopolymers or copolymers of N-vinyl-pyrrolidones
• CPC Class Codes: C09J 2301/302 the adhesive being pressure-sensitive, i.e. tacky at temperatures inferior to 30°C

Abstract

Novel, hydrophilic, skin-compatible, pressure sensitive, solid, adhesive gel hydrogel composition comprising 25 to 50 weight percent polyvinyl pyrolidone (PVP) preferably having a molecular weight in the range of about 100,000 to 600,000, 2 to 5 weight percent polyvinyl alcohol (PVA) preferably having a molecular weight in the range of about 150,000 to 300,000, about 5 to about 40 weight percent humectant, about 3 to about 50 weight percent water, about 0 to about 50 weight percent of an ionic species. In a preferred aspect, the composition of the invention is utilized in an iontophoresis device to provide a hydrophilic gel matrix from which a drug is iontophoretically delivered.

Claims

1. A skin-compatible, hydrophilic adhesive composition comprising:

25 to 50 weight percent polyvinyl pyrrolidone having a molecular weight in the range of 100,000 to 600,000;

2 to 5 weight percent polyvinyl alcohol having a molecular weight in the range of 150,000 to 300,000;

5 to 40 weight percent polar plasticizer;

3 to 50 weight percent water; and

about 0 to 50 weight percent of an ionic or nonionic species.

2. A biomedical adhesive according to claim 1 wherein there is from about 30 to 40 weight percent polyvinyl pyrrolidone.

3. A biomedical composition according to claim 1 wherein there is about 3 to 4 weight percent polyvinyl alcohol.

4. A biomedical composition according to claim 1 wherein the polyvinyl pyrrolidone has a molecular weight in the range of about 300,000 to 400,000.

5. A biomedical composition according to claim 1 wherein the polyvinyl alcohol has a molecular weight in the range of about 170,000 to 220,000.

6. A biomedical composition according to claim 1 wherein the polar plasticizer is glycerol.

7. A biomedical composition according to claim 1 wherein the polar plasticizer is sorbitol.

8. A biomedical composition according to claim 1 wherein the polar plasticizer is poly(ethylene)glycol.

9. A biomedical composition according to claim 1 which further includes from about 0 to about 20 weight percent of an additive.

10. A biomedical composition according to claim 9 wherein the additive is selected from the group consisting of hydroxy propyl methyl cellulose, carboxy methyl cellulose, cellulose, hydroxy propyl guar, dextran or silica.

11. A composition according to claim 1 which includes an additive selected from the group consisting of poly-2-acrylamido 2-methyl propane sulfonic acid, polyacrylic acid, polystyrene sulfonic acid, salts thereof, karaya, xanthan, guar or locust bean gums.