Transdermal dosimeter and method of use

• US 4,595,011 A
• Filed: 07/18/1984
• Issued: 06/17/1986
• Est. Priority Date: 07/18/1984
• Status: Expired due to Fees

• Current Assignee: Michael Phillips
• Original Assignee: Michael Phillips
• Inventors: Phillips, Michael
• Primary Examiner(s): NOT, DEFINED
• Application Number:
  US06/632,127
• Time in Patent Office: 699 Days
• Field of Search: 128/760, 128/771, 128/762, 128/632, 128/635, 128/636, 128/638, 128/640, 204/403, 435/817, 422/58, 604/312
• US Class Current: 600/362
• CPC Class Codes: A61B 10/0064 for taking sweat or sebum samples measuring sweat production A61B5/4266
• CPC Class Codes: A61B 2010/0009 Testing for drug or alcohol abuse
• CPC Class Codes: A61B 5/14514 using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/4266 sweat secretion
• CPC Class Codes: A61B 5/441 Skin evaluation, e.g. for skin disorder diagnosis
• CPC Class Codes: A61B 5/4881 Determining interstitial fluid distribution or content within body tissue measuring analytes in interstitial fluid in-vivo A61B5/1451
• CPC Class Codes: G01N 31/22 using chemical indicators G01N31/02 takes precedence

Abstract

A transdermal dosimeter, a device used to monitor exposure to chemical agents is disclosed. The device is attached to the skin surface and functions by causing the uptake of compounds that are excreted through the skin.

Claims

1. A transdermal dosimeter for use in a diagnostic test which comprises:

(a) a sealed container constructed of chemically intert, flexible, fluid-tight, adhesive material;

(b) a dermal contact bridge in the container which comprises a fluid component and a support means component for supporting the fluid component within the container;

(c) a collecting component means in the container and in contact with the dermal contact bridge, for providing storage for fluid substances collected from the dermal contact bridge, said collecting component means being impregnated with an osmotically active crystalloid material; and

(d) a process component in the container made of fluid absorbent material containing a chemical reagent which reacts with the stored substances, said process component being in contact with the collecting component.

2. The apparatus of claim 1 wherein the fluid is aqueous.

3. The apparatus of claim 2 wherein the fluid contains an osmotically active solute.

4. The apparatus of claim 2 wherein the fluid is saline.

5. The apparatus of claim 2 wherein the fluid is saturated with NaCl.

6. The apparatus of claim 5 wherein the fluid is mineral oil.

7. The apparatus of claim 5 wherein the fluid is vegetable oil.

8. The apparatus of claim 7 wherein the fluid is polyethylene glycol.

9. The apparatus of claim 1 wherein the fluid is lipid.

10. The apparatus of claim 1 wherein the fluid is organic.

11. The apparatus of claim 1 wherein the support means is of cellulose-type material.

12. The apparatus of claim 11 wherein the support means is a high molecular weight polyethylene glycol.

13. The apparatus of claim 11 wherein the support means is a gel.

14. The apparatus of claim 1 wherein the support means is an inert polymer.

15. The apparatus of claim 1 wherein the support means is a viscous organic compound.

16. The apparatus of claim 1 wherein the processing component contains a non-specific binding agent.

17. The apparatus of claim 1 wherein the processing component contains activated charcoal.

18. The apparatus of claim 1 wherein the processing component contains a specific binding agent.

19. The apparatus of claim 1 wherein the processing component contains an antibody.

20. The apparatus of claim 1 wherein the chemical reagent include an enzyme and chemical agents to form colored compounds from the products of the enzymically catalyzed reactions.

21. The apparatus of claim 1 wherein the chemical reagent include chemical compounds which can react with substances present in human tissue fluids to yield a colored product.

22. The appratus of claim 1 wherein the processing component contains silver nitrate.

23. The apparatus of claim 1 wherein the dermal contact bridge and the collecting component are combined into a single layer.

24. The apparatus of claim 23 wherein the single layer comprises a solid absorptive matrix pre-soaked in fluid.

25. The apparatus of claim 23 wherein the single layer comprises a semi-solid absorptive matrix.

26. The apparatus of claim 1 wherein the dermal contact bridge, the collecting component, and the processing component are combined into a single layer.

27. The apparatus of claim 26 wherein a binding agent is incorporated.

28. The apparatus of claim 27 wherein the binding material is activated charcoal.

29. The apparatus of claim 27 wherein the binding material is a resin.

30. The apparatus of claim 26 wherein a chemical conversion agent is incorporated.

31. A diagnostic test, which comprises the steps of:

providing a dosimeter which comprises;

(a) a sealed container constructed of chemically inert, flexible, fluid-tight, adhesive material;

(b) a dermal contact bridge which comprises a fluid component and a support means component for supporting the fluid component within the container;

(c) a collecting component means in the container and in contact with the dermal contact bridge, for providing storage for fluid substances collected from the dermal contact bridge, said collecting component means being impregnated with an osmotically active crystalloid material; and

(d) a process component in the container made of fluid absorbent material containing a chemical reagent which reacts with the stored substances, said process component being in contact with the collecting component;

affixing the dosimeter to the skin of a test subject;

removing the dosimeter after a period of time; and

determining the results of the test.