Imaging probe and method

• US 4,595,014 A
• Filed: 10/18/1983
• Issued: 06/17/1986
• Est. Priority Date: 10/18/1983
• Status: Expired due to Fees

• Current Assignee: University Patents, Inc.
• Original Assignee: University Patents, Inc.
• Inventors: Barrett, Harrison H., Barber, Herbert B., Wild, Walter J.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): Smith, Ruth S.
• Application Number:
  US06/542,953
• Time in Patent Office: 973 Days
• Field of Search: 128/653, 128/654, 128/659, 250/363 SD, 250/363 SR, 250/368, 250/370 GX, 378/2, 378/149, 378/150
• US Class Current: 600/431
• CPC Class Codes: A61B 6/4057 by using radiation sources located in the interior of the body A61B6/037 takes precedence
• CPC Class Codes: A61B 6/425 using detectors specially adapted to be used in the interior of the body
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: G01T 1/161 Applications in the field of nuclear medicine, e.g. in vivo counting apparatus for radiation diagnosis A61B6/00
• CPC Class Codes: G01T 1/295 using coded aperture devices, e.g. Fresnel zone plates handling of radiation of particles, e.g. using diaphragms, collimators, diffraction G21K1/00

Abstract

The disclosure is directed to an apparatus and method for imaging radiation pattern from within a body. In accordance with the preferred method of the invention, there is provided a technique for imaging internal structure of a body which includes the following steps: a radiation-emitting substance is introduced into the body. A miniaturized probe is inserted into the body, the probe being coupled to a cable and including at least one radiation detector surrounded by a coded aperture. Signals are received from the detector via the cable for a series of positions of the probe and for different orientations of the coded aperture with respect to the body. The signals from the detector are processed to obtain an image of the radiation pattern within the body. The imaging hereof allows both the position and the strength of a source (e.g. a tumor) to be determined in the presence of background radiation. The use of an internal probe simultaneously allows advantage to be taken of the increase in count rate and resolution resulting from proximity to the source.

Claims

1. A method for imaging internal structure of a body, comprising the steps of:

introducing a radiation-emitting substance into the body;

inserting into the body a minaturized probe coupled to a cable, the probe including a plurality of radiation detectors, each detector being surrounded by a respective coded aperture, the coded apertures being at different relative rotational orientations;

receiving signals from the detectors via the cable for a series of positional translations of the probe, without rotation of the probe; and

processing the signals from the detectors to obtain an image of a radiation pattern within the body.

2. The method as defined by claim 1, wherein said step of processing the signals from the detectors comprises correlating said signals with the coded aperture pattern.

3. The method as defined by claim 1, wherein said processing step comprises processing successive cylindrical image strips to obtain a cylindrical image about the axis of the probe.

4. Apparatus for imaging a radiation pattern from within a body, comprising:

a cable;

a minaturized probe coupled to the cable and insertable into the body, the probe including;

a plurality of radiation detectors separated by parallel radiation-opaque axial collimators;

each detector having an associated azimuthal collimator ring with a coded aperture pattern thereon, said collimator rings being disposed around their respective detectors, the coded aperture patterns of said collimator rings being at different relative rotational orientations;

means for obtaining output signals from said detectors for a series of positional translations of said probe; and

means responsive to said output signals for processing said output signals to obtain an image.

5. Apparatus as defined by claim 4, wherein said azimuthal collimator rings comprise a cylinder formed of a radiation-opaque material having radiationtransparent apertures therein.

6. Apparatus as defined by claim 5, wherein the opaque regions and apertures in the cylinder are formed in a pattern of a uniformly redundant array binary code.

7. Apparatus as defined by claim 4 wherein said means for processing said output signals to obtain an image includes means for correlating said output signals with the coded aperture pattern of said collimator rings.

8. Apparatus as defined by claim 4 further comprising means for determining the position of said probe, and wherein said means for processing said output signals to obtain an image is also responsive to indications of the position of said probe.

9. Apparatus as defined by claim 8, wherein said means for determining the position of said probe comprises means for determining the length of said cable.

10. Apparatus as defined by claim 4 wherein said means for obtaining output signals from said detectors includes means for applying said output signals for transmission through said cable.

11. Apparatus as defined by claim 10 wherein said means for processing said output signals to obtain an image includes means operative to correlate said output signals with a coded aperture pattern derived from the aperture pattern of said azimuthal collimator rings.

12. Apparatus as defined by claim 11, wherein said means for processing said output signals includes means for combining delayed versions of the output signals from different ones of said radiation detectors.

13. Apparatus as defined by claim 11, wherein each of said azimuthal collimator rings has the same coded aperture pattern thereon.

14. Apparatus as defined by claim 10 wherein the number of said radiation detectors corresponds to the number of elemental rotational positions of said azimuthal collimator rings.

15. Apparatus as defined by claim 14 wherein said means for processing said output signals includes means for combining delayed versions of the output signals from different ones of said radiation detectors.

16. Apparatus as defined by claim 14 wherein each of said azimuthal collimator ring has the same coded aperture pattern thereon.

17. Apparatus as defined by claim 10 wherein each of said azimuthal collimator rings has the same coded aperture pattern thereon.