Minute ventilation dependent rate responsive pacer

• US 4,596,251 A
• Filed: 10/10/1984
• Issued: 06/24/1986
• Est. Priority Date: 02/07/1984
• Status: Expired due to Term

• Current Assignee: Biotec International SPA, Schiapparelli Medtronic SPA
• Original Assignee: Biotec International SPA
• Inventors: Plicchi, Gianni, Canducci, Giancarlo
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US06/659,542
• Time in Patent Office: 622 Days
• Field of Search: 128/419 PG, 128/716, 128/721-725, 128/734
• US Class Current: 607/20
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

An electronic circuit included in a pacer detects the impedance between two electrodes connected to it and made up by the conducting part of the pacer case (B) and by an auxiliary subcutaneous lead placed in the chest or by an electrode placed on the insulating part (C) of the case itself. The changing geometry of the chest, due to pulmonary ventilation, determines the impedance variations. The electronic circuit, by processing the impedance signal is able to automatically adjust the stimulation rate of the ventricle and/or of the atrium between minimum and maximum preset values according to the activity levels of the patient.

Claims

1. An implantable rate responsive pacer arranged to be implanted in a patient and comprising:

pacer control means for producing control pulses for controlling cardiac activity at a rate which is variable between selected upper and lower limits as a function of the metabolic demand of the patient;

means connected to said pacer control means for producing heart stimulation pulses in response to the control pulses; and

measurement circuit means responsive to respiratory activity of the patient for producing a signal representative of the change in volume of air in the patient'"'"'s lungs, corresponding to pulmonary minute ventilation, that is the quantity of air inhaled by the patient in unit time, said measurement circuit means being connected to said pacer control means for controlling the rate of the control pulses on the basis of the signal.

2. The pacer of claim 1 wherein said measurement circuit means comprise means for detecting variations with respect to time in the geometry of at least part of the chest of the patient due to pulmonary activity.

3. The pacer of claim 2 wherein said means for detecting variations comprise two electrodes implantable for monitoring such variations in chest geometry, and monitoring means connected to said electrodes for monitoring the electrical impedance present between said electrodes, and wherein said measurement circuit means further comprise signal processing means connected to said monitoring means for producing the signal dependent on minute ventilation, and wherein said electrodes are arranged to be placed in a position which guarantees that the activity monitored is substantially unaffected by movements other than respiration.

4. The pacer of claim 3 further comprising an implantable conductive case constituting the other one of said electrodes, and wherein said one of said electrodes is arranged to be implanted at a selected distance from said case.

5. The pacer of claim 3 further comprising an implantable conductive case having:

two electrically conductive parts each constituting a respective one of said electrodes; and

means electrically insulating said two conductive parts from one another.

6. The pacer of claim 3 wherein said monitoring means comprise means for monitoring the impedance at regularly spaced sampling times.

7. The pacer of claim 6 wherein the sampling times occur at a rate of approximately 10 Hz.

8. The pacer of claim 6 wherein:

said monitoring means comprise an impedance/voltage converter for producing signal pulses V(Z_AB) which correspond in amplitude to the impedance present between said electrodes at successive sampling times; and

said signal processing means comprise a calculating circuit producing a first signal V'"'"'(Δ

A_AB) representing the absolute values of the amplitude variations between successive signal pulses, and low-pass filter means having a time constant of a few tens of seconds and connected to said calculating circuit for producing a second signal Vm(Δ

Z_AB) which is based on the first signal and which represents the mean values or the average of the absolute values of the amplitude variations between successive signal pulses, said second signal constituting said signal dependent on pulmonary minute ventilation.

9. The pacer of claim 8 further comprising a programmable correlation connected to receive the second signal from said filter means and for associating two selected values of said second signal with two respective control pulse rate values, whereby the rate at which cardiac activity is controlled depends on the value of said second signal.

10. A control circuit for an active device implantable in a patient, the active device being operable at a controllable rate, and said control circuit producing an output signal which controls the operating rate of the active device, said control circuit comprising:

means for detecting variations with respect to time in the geometry of at least part of the chest of the patient due to pulmonary ventilation and for producing a first signal representative of such variations; and

circuit means connected to said means for detecting variations, and responsive to the first signal, for producing a second signal which is representative of the change in volume of air in the patient'"'"'s lungs, corresponding to the patient'"'"'s minute ventilation and which constitutes the output signal from said control circuit.

11. The control circuit of claim 10 wherein said means for detecting variations comprise two electrodes implantable for monitoring such variations in chest geometry, and monitoring means connected to said electrodes for monitoring the electrical impedance present between said electrodes, and wherein said circuit means comprise signal processing means connected to said monitoring means for producing the signal dependent on minute ventilation, and wherein said electrodes are arranged to be placed in a position which guarantees that the activity monitored is substantially unaffected by movements other than respiration.

12. The control circuit of claim 11 further comprising an implantable conductive case constituting the other one of said electrodes, and wherein said one of said electrodes is arranged to be implanted at a selected distance from said case.

13. The control circuit of claim 11 further comprising an implantable conductive case having:

two electrically conductive parts each constituting a respective one of said electrodes; and

means electrically insulating said two conductive parts from one another.

14. The control circuit of claim 11 wherein said monitoring means comprise means for monitoring the impedance at regularly spaced sampling times.

15. The control circuit of claim 14 wherein the sampling times occur at a rate of approximately 10 Hz.

16. The control circuit of claim 14 wherein:

said monitoring means comprise an impedance/voltage converter for producing signal pulses V(Z_AB) which corresponds in amplitude to the impedance present between said electrodes at successive sampling times; and

said signal processing means comprise a calculating circuit producing a first signal V'"'"'(Δ

Z_AB) representing the absolute values of the amplitude variations between successive signal pulses, and low-pass filter means having a time constant of a few tens of seconds and connected to said calculating circuit for producing a second signal Vm(Δ

Z_AB) which is based on the first signal and which represents the mean value or the average of the absolute values of the amplitude variations between successive signal pulses, said second signal constituting said signal dependent on pulmonary minute ventilation.

17. The control circuit of claim 16 further comprising a programmable correlation connected to receive the second signal from said filter means and for associating two selected values of said second signal with two respective control pulse rate values, whereby the rate at which the active device operates is controlled in dependence on the value of said second signal.