Biodegradable porous ceramic delivery system for bone morphogenetic protein

• US 4,596,574 A
• Filed: 05/14/1984
• Issued: 06/24/1986
• Est. Priority Date: 05/14/1984
• Status: Expired due to Term

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Urist, Marshall R.
• Primary Examiner(s): GRIFFIN, RONALD
• Application Number:
  US06/609,810
• Time in Patent Office: 771 Days
• Field of Search: 424/14, 424/357, 424/95, 3/1.9, 3/1.912, 3/1.913, 623/16, 623/22, 623/23
• US Class Current: 424/422
• CPC Class Codes: A61F 2310/00293 containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61K 9/2009 Inorganic compounds
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/227 Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
• CPC Class Codes: A61L 27/46 with phosphorus-containing inorganic fillers
• CPC Class Codes: C08L 89/00 Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00

Abstract

Disclosed is a biodegradable porous ceramic delivery system useful for delivery of bone morphogenic protein (BMP) to viable tissue and to induce formation of new bone therein. The delivery composite is substantially pure BMP in combination with a biodegradable porous ceramic (sintered), e.g. beta-tricalcium phosphate, and may be prepared by admixing the BMP with the porous ceramic material. The composition is implanted in viable tissue where the BMP is slowly released and induces formation of new bone.

Claims

1. A composition comprising a physiologically acceptable, biodegradable porous ceramic containing bone morphogenic protein (BMP).

2. A composition according to claim 1, wherein the physiologically acceptable, biodegradable porous ceramic is composed of a salt having a cation selected from the group consisting of physiologically acceptable alkali metals, alkaline earth metals, and transition metals and an anion selected from the group consisting of phosphate, sulfate, carbonate and silicate.

3. A composition according to claim 2, wherein the porous ceramic has a sintered, vitreous or glass-like form.

4. A composition according to claim 3, wherein the cation is selected from the group consisting of sodium, potasium, calcium, magnesium, manganese, vandium, iron, copper, zinc, silver, gold, aluminum, cobalt and platinum.

5. A composition according to claim 1, wherein the physiologically acceptable, biodegradable porous ceramic is a sintered mass of tricalcium phosphate (TCP).

6. A composition according to claim 1, wherein the physiologically acceptable, biodegradable porous ceramic is a sintered mass of beta tricalcium phosphate (BTCP).

7. A system for delivering bone morphogenic protein (BMP) to viable tissue and inducing formation of new bone therein, comprising:

a physiologically acceptable, biodegradable porous ceramic containing substantially pure bone morphogenic protein (BMP).

8. A delivery system according to claim 7, wherein the ceramic is sintered, porous beta tricalcium phosphate (BTCP).

9. The delivery system according to claim 8, wherein the weight ratio of BMP to sintered porous BTCP is at least about 1 part BMP to about 100 parts sintered porous BTCP.

10. A delivery system according to claim 9, wherein the sintered porous beta tricalcium (BTCP) has a Ca/P ratio of about 1.5.

11. A delivery system according to claim 10, wherein the weight ratio is in the range of about 1 part bone morphogenic protein (BMP) to 19 parts sintered porous BTCP.

12. A delivery system according to claim 9, wherein the sintered porous beta tricalcium phosphate (BTCP) has a Ca/P ratio of about 1.66.

13. A delivery system acocrding to claim 7, further comprising a radioopacifying agent contained in said ceramic.

14. A delivery system according to claim 7, further comprising an antibiotic contained in said ceramic.

15. An artificial appliance comprising a prosthesis bone device in combination with a delivery system according to claim 7.

16. A method for inducing formation of new bone in viable tissue, comprising:

implanting in said viable tissue a delivery system of a physiologically acceptable, biodegradable porous ceramic containing substantially pure BMP wherein the weight ratio is at least about 1 part BMP to about 100 parts porous ceramic.

17. A method for preparing a delivery system composite for delivering bone morphogenic protein (BMP) to viable tissue and inducing formation of new bone therein, comprising:

contacting a physiologically acceptable, biodegradable porous ceramic with a liquid containing substantially pure BMP and removing said liquid therefrom so that an effective amount of BMP is entrapped in the porous ceramic.

18. A method according to claim 17, wherein the porous ceramic is composed of a salt having a cation selected from the group consisting of a physiologically acceptable alkali metal, a physiologically acceptable alkaline earth metal, and a physiologically acceptable transition metal;

and an anion selected from the group consisting of phosphate, sulfate, carbonate and silicate.

19. The method according to claim 18, wherein the cation is selected from the group consisting of sodium, potasium, calcium, magnesium, manganese, vanadium, iron, copper, zinc, silver, gold, aluminum, colbalt, and platinum.

20. A method according to claim 17, wherein the porous ceramic is a sintered mass of TCP.

21. A method according to claim 20, wherein the sintered mass is beta tricalcium phosphate (BTCP) which has a Ca/P ratio of about 1.5.

22. A method according to claim 21 wherein the weight ratio is in the range of about 1 part BMP to 19 parts BTCP.

23. A method according to claim 22 wherein the delivery system, further comprises an antibiotic contained in said ceramic.

24. The method according to claim 22 wherein the delivery system composite, further comprises a radioopacifying agent contained in said ceramic.

25. A method for preparing a prosthesis for implanting, which comprises:

providing a bone morphogenic protein (BMP) delivery system of a physiologically acceptable, biodegradable porous ceramic containing substantially pure BMP on at least a portion of the prosthesis.