Arrangement for measuring diffusing particles

• US 4,597,392 A
• Filed: 04/02/1984
• Issued: 07/01/1986
• Est. Priority Date: 04/12/1983
• Status: Expired due to Term

• Current Assignee: Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften e.V. (Max-Planck-Gesellschaft zur Frderung der Wissenschaften e)
• Original Assignee: Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften e.V. (Max-Planck-Gesellschaft zur Frderung der Wissenschaften e)
• Inventors: Lubbers, Dietrich W., Opitz, Norbert
• Primary Examiner(s): Davis, Curtis R.
• Application Number:
  US06/597,105
• Time in Patent Office: 820 Days
• Field of Search: 128/634, 128/635, 128/636, 128/637, 128/633, 128/665, 128/666, 128/745, 351/221, 356/38, 356/39, 356/317, 356/318
• US Class Current: 600/321
• CPC Class Codes: A61B 3/0008 provided with illuminating means A61B3/117 takes precedence; goniolenses used for laser treatment A61F9/009; illuminating means for optical instruments G02B27/00
• CPC Class Codes: A61B 5/14556 by fluorescence A61B5/14555 takes precedence
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/6821 Eye
• CPC Class Codes: G01N 2021/7786 Fluorescence
• CPC Class Codes: G01N 21/6428 Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" in vivo A61B5/00; immunoassay G01N33/53

Abstract

An arrangement for measuring diffusing particles has at least one monochromatic radiation source and a light measuring device, as well as at least one material limited particle-permeable indicator chamber provided with an optical fluorescent indicator which is optically changeable by the particles to be measured, and a carrier body having a surface which is arranged to face an eyelid and has depressions in which the indicator chambers are arranged.

Claims

1. An arrangement for measuring diffusing particles comprising a plurality of material limited indicator chambers permeable to the particles to be measured and provided with optical fluorescent indicators which are optically changeable by the particles for simultaneously measuring several physical parameters and/or several types of particles, said indicator chambers being formed as optodes;

a carrier body having a surface arranged to lie on a lid under the latter and provided in this surface with depressions in which said optodes are arranged;

at least one monochromatic irradiation source arranged to irradiate said optodes; and

a light measuring device arranged to measure light going out of the optodes and its change.

2. An arrangement as defined in claim 1, wherein said carrier body has an edge provided with at least one coupling surface;

and further comprising light conductors provided inside said carrier body and guiding light from said at least one coupling surface to said indicator chambers.

3. An arrangement as defined in claim 1, wherein said indicator chambers are arranged in said depressions of said carrier body at such a location that measurements through the eyelid can be performed.

4. An arrangement as defined in claim 1, wherein said light measuring device includes a radiation receiver, said monochromatic radiation source and said radiation receiver being arranged in said carrier body, so that the irradiation of the optodes and the measurement of the radiation change is performed directly in said carrier body.

5. An arrangement as defined in claim 1;

and further comprising means for optical disengagement formed by layers arranged at a side facing toward the retina.

6. An arrangement as defined in claim 5, wherein said layers of said optical disengagement means are formed as reflecting layers.

7. An arrangement as defined in claim 5, wherein said layers of said optical disengagement means are formed as absorbing layers.

8. An arrangement as defined in claim 1, wherein said light measuring device is arranged inside said carrier body.

9. An arrangement as defined in claim 1, wherein said carrier body has a recess, said light conducting devices being formed as one-piece elements received in said recess.

10. An arrangement as defined in claim 8, wherein said carrier body has a recess, said light measuring device being arranged in said recess of said carrier body.