Iontophoresis intermediary material and contact solution for the treatment of chronic pain syndromes

• US 4,602,909 A
• Filed: 02/07/1983
• Issued: 07/29/1986
• Est. Priority Date: 02/09/1982
• Status: Expired due to Fees

• Current Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
• Original Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
• Inventors: Szucs, Attila, Csillik, Bertalan, Knyihar, Erzsebet
• Primary Examiner(s): Grifffin, Ronald W.
• Application Number:
  US06/464,573
• Time in Patent Office: 1,268 Days
• Field of Search: 514/283, 514/863, 604/20
• US Class Current: 604/20
• CPC Class Codes: A61K 31/475 having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine vincamine A61K31/4375
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61P 25/02 for peripheral neuropathies

Abstract

A method of treating chronic pain is disclosed which comprises the step of topically administering to the skin of a human patient, 1 to 100 μg/cm² of body surface of a compound of the Formula (I) ##STR1## in which R is --CH₃ or --CHO

R¹ is methoxy or amino;

R² is hydrogen, hydroxyl or acetoxy;

R³ is hydrogen or ethyl;

R⁴ and R⁵ together form a valency bond or an epoxy bridge, or R⁴ is hydroxy or ethyl; and

R⁵ is hydrogen; or a pharmaceutically acceptable acid addition salt thereof, by iontophoresis.

Claims

1. A method of treating a chronic pain syndrome in a human, which comprises the step of topically administering to the skin of the human 1 to 100 μ

g/cm² of body surface of a compound of the Formula (I) ##STR3## in which R is --CH₃ or --CHO;

R¹ is methoxy or amino;

R² is hydrogen, hydroxyl or acetoxy;

R³ is hydrogen or ethyl;

R⁴ and R⁵ together form a valency bond or an epoxy bridge, or R⁴ is hydroxyl or ethyl; and

R⁵ is hydrogen;

or a pharmaceutically acceptable acid addition salt thereof, by iontophoresis.

2. The method of treating a chronic pain syndrome defined in claim 1 wherein the compound of the Formula (I) is vinblastine in the form of its sulfate acid addition salt.

3. The method of treating a chronic pain syndrome defined in claim 1 wherein the compound of the Formula (I) is vincristine in the form of its sulfate acid addition salt.

4. The method of treating a chronic pain syndrome defined in claim 1 wherein the chronic pain syndrome is postherpetic neuralgia.