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Cyclic octapeptides and pharmaceutical preparations thereof, as well as processes for their manufacture, and their use

  • US 4,603,120 A
  • Filed: 12/20/1982
  • Issued: 07/29/1986
  • Est. Priority Date: 12/24/1981
  • Status: Expired due to Fees
First Claim
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1. A compound selected from the group consisting of(a) a cyclic octapeptide of the formula:

  • ##STR62## in which Aaa is the radical of a straight-chained α



    -diaminoalkanoic acid having from 4 to 7 carbon atoms;

    trp is the radical of L-Trp or D-Trp which is unsubstituted or substituted with halogen in the indole nucleus; and

    AcA is bound to the nitrogen of the terminal amino group of Aaa and is(i) hydrogen(ii) amidino,(iii) the acyl residue of Lys, Pro or Phe,(iv) the acyl residue of a di- or tripeptide of lysine.(b) a therapeutically acceptable salt thereof in which said octapeptide carries a charge and is comprised in the anionic or cationic moiety of the salt, and(c) a therapeutically acceptable complexes of said octapeptide with a metal compound or a polymeric organic peptide comlex-forming compound.

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