Modified cellulose separation matrix
First Claim
1. A method of substantially eliminating false positive Limulus Amebocyte Lysate ("LAL") tests for pyrogen from an effluent obtained from passing a biological liquid through a cellulose containing separation media comprising substituting for said separation media a cellulose containing separation media wherein said cellulose contains at least about 90% alpha-cellulose and is essentially free of non-specific pyrogenic reactivity as measured by the LAL tests, whereby said false positive LAL tests are substantially eliminated.
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Abstract
A cellulose-containing separation media for effecting separation of particulate and/or molecular components from a liquid, wherein the cellulose in the separation media is essentially free of non-specific pyrogenic activity as measured by the LAL test. The separation media include filtration media and chromatographic media.
76 Citations
32 Claims
- 1. A method of substantially eliminating false positive Limulus Amebocyte Lysate ("LAL") tests for pyrogen from an effluent obtained from passing a biological liquid through a cellulose containing separation media comprising substituting for said separation media a cellulose containing separation media wherein said cellulose contains at least about 90% alpha-cellulose and is essentially free of non-specific pyrogenic reactivity as measured by the LAL tests, whereby said false positive LAL tests are substantially eliminated.
Specification