Bone seeking Tc-99m complexes of phosphonate derivatives of polyamidoamines

• US 4,606,907 A
• Filed: 07/02/1984
• Issued: 08/19/1986
• Est. Priority Date: 07/02/1984
• Status: Expired due to Fees

• Current Assignee: The Dow Chemical Company (Dow, Inc.)
• Original Assignee: The Dow Chemical Company (Dow, Inc.)
• Inventors: Wilson, David A., Simon, Jaime, Volkert, Wynn A.
• Primary Examiner(s): Nucker, Christine M.
• Application Number:
  US06/626,816
• Time in Patent Office: 778 Days
• Field of Search: 424/1.1, 424/9, 534/14, 564/12, 260/502.5 R, 260/502.4 P
• US Class Current: 424/1.77
• CPC Class Codes: A61K 2123/00 Preparations for testing in vivo
• CPC Class Codes: A61K 51/0478 complexes from non-cyclic ligands, e.g. EDTA, MAG3
• CPC Class Codes: A61K 51/0489 Phosphates or phosphonates, e.g. bone-seeking phosphonates; phospholipids: A61K51/0408; nucleotides or nucleic acids: A61K51/0491
• CPC Class Codes: Y10S 424/16 Dendrimers and dendritic polymers

Abstract

New stable complexing agents for radionuclides which are phosphonate derivatives of certain polyamidoamines have been found which are useful in imaging the skeletal system in animals. Even though the complexing agents have high molecular weights the complexes clear rapidly and very efficiently through the kidneys, with large amounts being taken up in the bone. The ratio of uptake in bone to that in surrounding soft tissue is high even at relatively short times after injection.

Claims