Skin-marking compositions and devices, and their use
First Claim
1. A skin-marking composition adapted for temporarily identifying a defined area of the epidermis under visible light and rendering the area fluorescent for a prolonged period of time under ultraviolet light, comprising a non-fluorescing dermatologically acceptable solution of (a) a fugitive dye or pigment and (b) a skin fluorescingly effective amount of a furanone of the formula ##STR7## wherein R1 is lower alkoxy or phenyl lower alkoxy and R2 is ##STR8## or, R1 and R2 collectively are ##STR9## wherein R in each instance is hydrogen or one or more of halogen, lower alkyl, trifluoromethyl, lower alkoxy, nitro, cyano, carboxy or carboxy lower alkyl, and R3 is lower alkyl, phenyl lower alkyl or aryl, in a liquid vehicle in which the furanone compound is stable.
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Abstract
Fluorescamine or like compounds react with the epidermis when applied to the skin and form, within about 15 to 30 minutes after application to the skin, a long-lasting reaction product, which is invisible in ordinary light but which fluoresces intensely under ultraviolet light. Such markings resist removal by abrasion and repeated washings. Organic solutions of such compounds, preferably containing a fugitive dyestuff or pigment and used as the marking fluid of a conventional felt-tipped pen, can be used to mark skin for radiological or diagnostic purposes. Inanimate objects can be coated with these compounds to detect human contact therewith.
55 Citations
11 Claims
- 1. A skin-marking composition adapted for temporarily identifying a defined area of the epidermis under visible light and rendering the area fluorescent for a prolonged period of time under ultraviolet light, comprising a non-fluorescing dermatologically acceptable solution of (a) a fugitive dye or pigment and (b) a skin fluorescingly effective amount of a furanone of the formula ##STR7## wherein R1 is lower alkoxy or phenyl lower alkoxy and R2 is ##STR8## or, R1 and R2 collectively are ##STR9## wherein R in each instance is hydrogen or one or more of halogen, lower alkyl, trifluoromethyl, lower alkoxy, nitro, cyano, carboxy or carboxy lower alkyl, and R3 is lower alkyl, phenyl lower alkyl or aryl, in a liquid vehicle in which the furanone compound is stable.
- 6. In a marking device having a housing, a fluid reservoir in the housiong containing a marking fluid, and a marking tip in communication with the fluid in the reservoir, the improvement wherein the marking fluid is a nonfluorescing dermatologically acceptable solution of a skin fluorescingly effect amount of a furanone of the formula ##STR10## wherein R1 is lower alkoxy or phenyl lower alkoxy and R2 is ##STR11## or, R1 and R2 collectively are ##STR12## wherein R in each instance is hydrogen or one or more of halogen, lower alkyl, trifluoromethyl, lower alkoxy, nitro, cyano, carboxy or carboxy lower alkyl, and R3 is lower alkyl, phenyl lower alkyl or aryl, in a liquid medium in which the furanone compound is stable.
- 9. A method for indetectably rendering human contact with an inanimate object detectable which comprises applying to a surface of the object, a fluorogenically-effective amount of a furanone of the formula ##STR13## wherein R1 is lower alkoxy or phenyl lower alkoxy and R2 is ##STR14## or, R1 and R2 collectively are ##STR15## wherein R is each instance is a hydrogen or one or more of halogen, lower alkyl, trifluoromethyl, lower alkoxy, nitro, cyano, carboxy or carboxy lower alkyl, and R3 is lower alkyl, phenyl lower alkyl or aryl, thereby rendering the portion of the skin of any person who contacts the thus-treated object fluorescent under ultraviolet light for a period of up to about 21 days.
Specification