Apparatus for examining a biological object by using radiation

• US 4,611,340 A
• Filed: 05/17/1984
• Issued: 09/09/1986
• Est. Priority Date: 05/20/1983
• Status: Expired due to Term

• Current Assignee: Toshiba Corporation
• Original Assignee: Kabushiki Kaisha Toshiba (Toshiba Corporation)
• Inventors: Okazaki, Kiyoshi
• Primary Examiner(s): Anderson, Bruce C.
• Assistant Examiner(s): Grigsby, T. N.
• Application Number:
  US06/611,150
• Time in Patent Office: 845 Days
• Field of Search: 378/95, 378/99, 378/8, 128/708, 128/709, 358/111
• US Class Current: 378/95
• CPC Class Codes: A61B 6/469 for selecting a region of interest [ROI]
• CPC Class Codes: A61B 6/481 involving the use of contrast agents
• CPC Class Codes: A61B 6/504 for diagnosis of blood vessels, e.g. by angiography
• CPC Class Codes: A61B 6/541 involving acquisition triggered by a physiological signal
• CPC Class Codes: H04N 5/3205 using subtraction imaging techniques

Abstract

In an angiographic apparatus, operation timings of an entire system, e.g., an X-ray generator, an X-ray detector, a transmission image processor, and an injector for X-ray contrast medium are controlled in synchronism with cardiac beat waves of a biological object.

Claims

1. An apparatus for producing video difference images of an object having heart beats from X-ray images obtained from X-ray radiation passed through that object, comprising:

means for detecting said heart beats of the object to be diagnosed;

means for producing first video signals corresponding to a first X-ray image occurring at a predetermined phase of a first one of said heart beats;

means for subsequently injecting said object with an X-ray contrast media;

means for producing second video signals corresponding to a second X-ray image occurring at the same phase of a later second one of said heart beats as that of said first heart beat, delayed from said first heart beat by a predetermined number of said heart beats dependent upon the expected distribution of said X-ray contrast media within said object;

means for subtracting said first video signals from said second video signals to produce difference video signals of said object; and

means for displaying an X-ray image of said object corresponding to said difference video signals.

2. An apparatus for examining a biological object by using radiation comprising:

means for generating radiation;

means for controlling the radiation generating means so as to irradiate the radiation toward the biological object at a predetermined time period;

means for detecting the radiation which has been transmitted through the biological object and for producing a radiation transmission image thereof as a digital image signal;

means for processing a plurality of digital image signals in a digital subtraction method so as to obtain a plurality of subtraction image signals;

means for displaying at least a subtraction image of the biological object obtained from the subtraction image signals;

means for measuring cardiac beat waves of the biological object;

means for administrating a radiation contrast medium into the biological object;

system control means for performing at least timing controls of the apparatus in synchronism with the cardiac beat waves of the biological object as a reference signal;

wherein;

the radiation generating means generates X-rays;

the detecting means produces at least a first transmission image as a mask image and a second transmission image as a contrast image in conjunction with administration of the contrast medium;

the system control means includes a timing controller and a system console having a memory into which a predetermined timing program has been stored, whereby the timing controls of the apparatus are effected by the timing controller in synchronism with the cardiac beat waves under control of the predetermined control program;

and further wherein;

the X-rays are generated in the continuous condition from the radiation generating means;

the reference signal is derived from an R-wave of the cardiac beat waves; and

the timing controller includes;

an R-wave detector for detecting the R-waves from the cardiac beat waves by means of a threshold level detection;

an R-wave counter for counting the number of R-waves derived from the R-wave detector;

a first trigger generator for generating a first trigger signal based upon the predetermined timing program and the counted number of R-waves, whereby the first trigger signal the counted number of R-waves, whereby the first trigger signal is used to control operation timings of the radiation generating means and the radiation detecting means;

a second trigger generator for generating a second trigger signal based upon the predetermined timing program and the counted number of R-waves, whereby the second trigger signal is used to control an operation timing of the means for administrating a radiation contrast medium; and

a generator for generating a process control signal based upon the predetermined timing program and the counted number of R-waves, whereby the process control signal is used to control operation timings of the processing means for digital image signals and the displaying means.

3. An apparatus for examining a biological object by using radiation comprising:

means for generating radiation;

means for controlling the radiation generating means so as to irradiate the radiation toward the biological object at a predetermined time period;

means for detecting the radiation which has been transmitted through the biological object and for producing a radiation transmission image thereof as a digital image signal;

means for processing a plurality of digital image signals in a digital subtraction method so as to obtain a plurality of subtraction image signals;

means for displaying at least a subtraction image of the biological object obtained from the subtraction image signals;

means for measuring cardiac beat waves of the biological object;

means for administrating a radiation contrast medium into the biological object; and

system control means for performing at least timing controls of the apparatus in synchronism with the cardiac beat waves of the biological object as a reference signal;

wherein;

the radiation generating means generates X-rays;

the detecting means produces at least a first transmission image as a mask image and a second transmission image as a contrast image in conjunction with administration of the contrast medium;

the system control means includes a timing controller and a system console having a memory into which a predetermined timing program has been stored, whereby the timing controls of the apparatus are effected by the timing controller in synchronism with the cardiac beat waves under the control of the predetermined control program;

and further wherein;

the X-rays are generated in the pulsatory condition from the radiation generating means;

the reference signal is derived from an R-wave of the cardiac beat waves; and

the timing controller includes;

an R-wave detector for detecting the R-waves from the cardiac beat waves by means of a threshold level detection;

an R-wave counter for counting the number of R-waves derived from the R-wave detector;

a first trigger generator for generating a first trigger signal based upon the predetermined timing program and the counted number of R-waves;

a projection control circuit into which the first trigger signal is applied and also projection numbers of the pulsatory X-rays, a pulse width and a repetition time of the pulsatory X-rays are applied as the predetermined timing program from the system console and from which a projection control signal is derived so as to control operation timings of the radiation generating means and the radiation detecting means;

a second trigger generator for generating a second trigger signal based upon the predetermined timing program and the counted number of R-waves, whereby the second trigger signal is used to control an operation timing of the administrating means for contrast medium; and

a generator for generating a process control signal based upon the predetermined timing program and the counted number of R-waves, whereby the process control signal is used to control operation timings of the processing means for digital image signals and the displaying means.

4. An apparatus as claimed in claim 3, wherein the first trigger generator includes a register for temporarily storing the counted numbers of the R-wave and the predetermined timing program, and a comparator for comparing the counted numbers of the R-wave to the predetermined timing program whether the counted numbers are coincident with predetermined numbers of the predetermined timing program.