Osmotic device with dual thermodynamic activity
DCFirst Claim
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1. An osmotic device for the delivery at a controlled rate a beneficial agent to an environment of use, the osmotic device comprising:
- (a) a wall comprising in at least a part a semipermeable composition permeable to the passage of an exterior fluid present in the environment of use and substantially impermeable to the passage of a beneficial agent, the wall surrounding and forming;
(b) a compartment;
(c) a first composition in the compartment, said first composition comprising a beneficial agent, an osmagent that exhibits an osmotic pressure gradient across the wall against an external fluid, and an osmopolymer that exhibits an osmotic pressure gradient across the wall against an external fluid;
(d) a second composition in the compartment, said second composition comprising an osmagent that exhibits an osmotic pressure gradient across the wall against an external fluid, and an osmopolymer that exhibits an osmotic pressure gradient across the wall against an external fluid; and
,(e) at least one passageway in the wall communicating with the first composition and the exterior of the device for delivering the beneficial agent through the passageway from the device.
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Abstract
An osmotic system is disclosed comprising a wall formed in at least a part of a semipermeable material that surrounds a compartment. The compartment contains a first osmotic composition comprising a beneficial agent, and a second and different osmotic composition. A passageway in the wall connects the first composition with the exterior of the system.
585 Citations
27 Claims
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1. An osmotic device for the delivery at a controlled rate a beneficial agent to an environment of use, the osmotic device comprising:
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(a) a wall comprising in at least a part a semipermeable composition permeable to the passage of an exterior fluid present in the environment of use and substantially impermeable to the passage of a beneficial agent, the wall surrounding and forming; (b) a compartment; (c) a first composition in the compartment, said first composition comprising a beneficial agent, an osmagent that exhibits an osmotic pressure gradient across the wall against an external fluid, and an osmopolymer that exhibits an osmotic pressure gradient across the wall against an external fluid; (d) a second composition in the compartment, said second composition comprising an osmagent that exhibits an osmotic pressure gradient across the wall against an external fluid, and an osmopolymer that exhibits an osmotic pressure gradient across the wall against an external fluid; and
,(e) at least one passageway in the wall communicating with the first composition and the exterior of the device for delivering the beneficial agent through the passageway from the device. - View Dependent Claims (2, 3, 4, 5, 6, 21, 22)
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7. An osmotic device for the controlled delivery of a beneficial drug to a biological environment of use, comprising:
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(a) a shaped wall permeable in at least a part to the passage of an exterior fluid present in the environment of use, and substantially impermeable to the passage of drug, the wall surrounding and forming; (b) a compartment comprising;
(1) a composition comprising a dosage amount of a drug, an osmotically effective compound that exhibits an osmotic pressure gradient across the wall against an external fluid, and a polymer that exhibits an osmotic pressure gradient across the wall against an external fluid, and (2) a composition comprising an osmotically effective compound that exhibits an osmotic pressure gradient across the wall against an external fluid, and a polymer that exhibits an osmotic pressure gradient across the wall against an external fluid; and
,(c) at least one passageway in the wall communicating with the exterior of the device and the composition comprising the drug for delivering a therapeutically effective amount of drug from the device at a controlled rate over a prolonged period of time. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 18, 19, 23, 24, 25)
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17. An osmotic device for the controlled delivery of a beneficial drug formulation to a biological environment of use, comprising:
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(a) a shaped wall permeable in at least a part to the passage of an exterior biological fluid and substantially impermeable to the passage of drug formulation, which wall surrounds and forms; (b) a compartment comprising;
(1) a drug formulation, which formulation comprises a drug that is insoluble to very soluble in the biological fluid, an osmotically effective solute that is soluble in the exterior fluid and exhibits an osmotic pressure gradient across the wall against the fluid and a polymer that imbibes fluid and absorbs fluid that enters the compartment; and
(2) a delivery formulation, which formulation comprises an osmotically effective solute that is soluble in the exterior fluid and exhibits an osmotic pressure gradient across the wall against the fluid and a polymer that imbibes fluid and absorbs fluid that enters the compartment; and
,(c) at least one passageway in the wall connecting the exterior of the device with the drug formulation for delivering the drug formulation from the device to the environment at a controlled rate over a prolonged period of time. - View Dependent Claims (26, 27)
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20. A composition of matter useful for forming a drug delivery system, the composition comprising in combination:
- (1) a first composition comprising a drug, an osmagent and an osmopolymer; and
, (2) a second composition in laminar arrangement with the first composition (1), which second composition (2) comprises an osmagent and an osmopolymer, and wherein compositions (1) and (2) exhibit an osmotic pressure gradient across a semipermeable polymeric film against fluid selected from the group consisting essentially of aqueous and biological fluids.
- (1) a first composition comprising a drug, an osmagent and an osmopolymer; and
Specification