Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements

• US 4,612,053 A
• Filed: 05/09/1985
• Issued: 09/16/1986
• Est. Priority Date: 10/06/1983
• Status: Expired

• Current Assignee: American Dental Association Health Foundation
• Original Assignee: American Dental Association Health Foundation
• Inventors: Chow, Laurence C., Brown, Walter E.
• Primary Examiner(s): NOT, DEFINED
• Application Number:
  US06/732,515
• Time in Patent Office: 495 Days
• Field of Search: 106/35, 433/199.1, 433/201.1, 433/202.1, 433/228.1
• US Class Current: 106/35
• CPC Class Codes: A61K 2800/594 Mixtures of polymers
• CPC Class Codes: A61K 6/54 Filling; Sealing
• CPC Class Codes: A61K 6/838 Phosphorus compounds, e.g. apatite
• CPC Class Codes: A61K 6/864 Phosphate cements apatite A61K6/838
• CPC Class Codes: A61K 8/24 Phosphorous; Compounds thereof
• CPC Class Codes: A61L 24/02 containing inorganic materials
• CPC Class Codes: A61L 2430/12 for dental implants or prostheses
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

Dental restorative compositions containing a mixture of Ca₄ (PO₄)₂ O and at least one different calcium phosphate.

Claims

1. A dental restorative slurry comprising an aqueous mixture of Ca₄ (PO₄)₂ O and at least one other calcium phosphate selected from the group consisting of CaHPO₄.2H₂ O, CaHPO₄, Ca₈ H₂ (PO₄)₆. 5H₂ O, α

--Ca₃ (PO₄)₂, β

--Ca₃ (PO₄)₂, and modified Ca₃ (PO₄)₂, both calcium phosphates being present in the slurry in excess such that hydroxyapatite is substantially continuously precipitated from the slurry.

2. The slurry of claim 1 wherein the other calcium phosphate is CaHPO₄.2H₂ O.

3. The slurry of claim 1 wherein the other calcium phosphate is CaHPO₄.

4. The slurry of claim 1 wherein the other calcium phosphate is Ca₈ H₂ (PO₄)₆.5H₂ O.

5. The slurry of claim 1 wherein the other calcium phosphate is β

--Ca₃ (PO₄)₂.

6. The slurry of claim 1 wherein at least one of the calcium phosphates is in crystalline, cryptocrystalline or amorphous form.

7. The slurry of claim 1 further comprising up to approximately 10% by weight of additional calcium or phosphate containing compounds.

8. The slurry of claim 7 wherein the additional calcium containing compounds comprise CaCl₂ or Ca(C₂ H₃ O₂)₂.

9. The slurry of claim 7 wherein the additional phosphate containing compounds comprise NaH₂ PO₄ or (NH₄)H₂ PO₄.

10. The slurry of claim 1 further comprising fluoride containing compounds such that the fluoride content of the slurry is up to approximately 3.8% by weight.

11. The slurry of claim 10 wherein the fluoride containing compounds comprise CaF₂, SnF₂, NaF, Na₂ SiF₆ or NaPO₃ F.

12. The slurry of claim 1 further comprising a gelling agent.

13. A dental restorative paste comprising a nonaqueous mixture of a nontoxic organic solvent, Ca₄ (PO₄)₂ O and at least one other calcium phosphate selected from the group consisting of CaHPO₄.2H₂ O, CaHPO₄, Ca₈ H₂ (PO₄)₆.5H₂ O, α

--Ca₃ (PO₄)₂, β

--Ca₃ (PO₄)₂ and modified Ca₃ (PO₄)₂, the paste being capable of hardening into a cement upon contact with an aqueous medium.

14. The paste of claim 13 wherein the other calcium phosphate is CaHPO₄.2H₂ O.

15. The paste of claim 13 wherein the other calcium phosphate is CaHPO₄.

16. The paste of claim 13 wherein the other calcium phosphate is Ca₈ H₂ (PO₄)₆.5H₂ O.

17. The paste of claim 13 wherein the other calcium phosphate is β

--Ca₃ (PO₄)₂.

18. The paste of claim 13 wherein at least one of the calcium phosphates is in crystalline, cryptocrystalline or amorphous form.

19. The paste of claim 13 further comprising up to approximately 10% by weight of additional calcium or phosphate containing compounds.

20. The paste of claim 19 wherein the additional calcium containing compounds comprise CaCl₂ or Ca(C₂ H₃ O₂)₂.

21. The paste of claim 19 wherein the additional phosphate containing compounds comprise NaH₂ PO₄ or (NH₄)H₂ PO₄.

22. The paste of claim 13 further comprising fluoride containing compounds such that the fluoride content of the slurry is up to approximately 3.8% by weight.

23. The paste of claim 22 wherein the fluoride containing compounds comprise CaF₂, SnF₂, NaF, Na₂ SiF₆ or NaPO₃ F.

24. The paste of claim 13 further comprising a seed crystal compound selected from the group consisting of hydroxyapatite and fluorapatite.

25. The paste of claim 13 wherein the aqueous medium is humid air or a dilute aqueous solvent.

26. A dental restorative powder comprising a mixture of Ca₄ (PO₄)₂ O and at least one other calcium phosphate selected from the group consisting of CaHPO₄.2H₂ O, CaHPO₄, Ca₈ H₂ (PO₄)₆. 5H₂ O, α

--Ca₃ (PO₄)₂, β

--Ca₃ (PO₄)₂, and modified Ca₃ (PO₄)₂, the powder being capable of forming a slurry upon contact with an appropriate aqueous solvent, the slurry being capable of substantially continuously precipitating hydroxyapatite.

27. The powder of claim 26 wherein the solvent is water or saliva.

28. A dental restorative powder comprising a mixture of Ca₄ (PO₄)₂ O and at least one other calcium phosphate selected from the group consisting of CaHPO₄.2H₂ O, CaHPO₄, Ca₈ H₂ (PO₄)₆.5H₂ O, α

--Ca₃ (PO₄)₂, β

--Ca₃ (PO₄)₂, and modified Ca₃ (PO₄)₂, the powder being capable of forming a hardenable cement upon contact with an appropriate aqueous solvent.

29. The powder of claim 28 wherein the solvent is water or saliva.