Coagulometer and method of measuring of the time of coagulation of samples of fluid products

• US 4,612,801 A
• Filed: 06/21/1985
• Issued: 09/23/1986
• Est. Priority Date: 06/27/1984
• Status: Expired due to Fees

• Current Assignee: Antoine Girolami
• Original Assignee: Antoine Girolami
• Inventors: Girolami, Antoine
• Primary Examiner(s): Levy, Stewart J.
• Assistant Examiner(s): ROSKOS, JOSEPH
• Application Number:
  US06/747,524
• Time in Patent Office: 459 Days
• Field of Search: 73/64.1, 356/39
• US Class Current: 73/64.41
• CPC Class Codes: G01N 33/4905 Determining clotting time of blood by chemical methods G01N33/86, C12Q1/54

Abstract

Method of measuring the time of coagulation of samples of fluid products such as, for example, samples of blood plasma, wherein the dose of liquid substance to be analyzed is introduced into a small cup (1) the base (1a) of which is shaped to serve as a circular rolling path (1b) for a ball (2) disposed in the lower part of the cup which is actuated with a non-rotary circular movement be means of an eccentric (3-3a) causing a rotation of the ball in a circular path in the base of the cup. The gradual slowing and/or halting of the rotary movement of the ball caused by the thickening or coagulation of the sample of the medium or liquid substance contained in the cup, for example following the introduction of a reactant, is ascertainable visually or, preferably, by any suitable automatic detection system.

Claims

1. A method, for ascertaining the progress of coagulation of a sample of liquid, comprising the steps of:

(i) introducing the sample into a cup having its base shaped to form an endless path for rolling of a ball disposed in said cup,

(ii) imparting to the cup, with the ball and sample therein, a constant non-rotary circulating motion to cause the ball to roll, in the liquid, in said path, and

(iii) detecting the occurrence of a slowing of the rolling of the ball resulting from thickening of the liquid.

2. The method claimed in claim 1 wherein the endless path is in a substantially horizontal plane, and wherein said step of detecting the occurrence of slowing of the rolling of the ball is performed by a detector means disposed adjacent to the cup.

3. The method claimed in claim 2 wherein said detecting step comprises passing rays through a transparent area, of a screen, aligned with a portion of the rolling path of said ball, and detecting variations of passage of the rays through said transparent area due to successive passes of the ball with a detector means generating correspondingly varying electrical potentials.

4. A coagulometer comprising:

(a) a cup to receive a sample of liquid, said cup including a base shaped to provide an endless rolling path for a ball;

(b) a ball disposed in said cup and rollable on said path;

(c) a base structure;

(d) guiding means interconnecting said base structure and said cup and permitting motion of the cup relative to said base structure;

(e) driving means connected to said cup for imparting to the cup a non-rotary circulating motion urging said ball to travel along said endless path.

5. A coagulometer, as claimed in claim 4, wherein said endless path is substantially horizontal, and further comprising detector means, for detecting movement of the ball along said path, disposed below said path.

6. A coagulometer, as claimed in claim 4, wherein said endless path is substantially horizontal, and further comprising detector means, for detecting movement of the ball along said path, disposed laterally of said path.

7. A coagulometer, as claimed in claim 5, comprising a source of rays disposed above said cup and arranged to project rays through said endless path for detection by said detector means.

8. A coagulometer, as claimed in claim 7, comprising an opaque screen positioned between said endless path and the detector means, said opaque screen including at least one area transparent to said rays.

9. A coagulometer, as claimed in claim 8, wherein said opaque screen is the base of the cup.

10. A coagulometer, as claimed in claim 8, wherein said opaque screen is a member disposed between the base of the cup and the detector means.

11. A coagulometer, as claimed in claim 4, wherein said guiding means comprises a movable plate to receive said cup, and flexible support means interconnecting said movable plate and said base structure.

12. A coagulometer, as claimed in claim 4, comprising thermostatically-controlled heating means for said cup.