Delivery system for desired agents

• US 4,613,330 A
• Filed: 10/18/1984
• Issued: 09/23/1986
• Est. Priority Date: 11/26/1982
• Status: Expired due to Fees

• Current Assignee: Paul E. Michelson
• Original Assignee: Paul E. Michelson
• Inventors: Michelson, Paul E.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): Vinyard, Sherri
• Application Number:
  US06/662,185
• Time in Patent Office: 705 Days
• Field of Search: 604/890-894
• US Class Current: 424/424
• CPC Class Codes: A61F 2/1616 Pseudo-accommodative, e.g. multifocal or enabling monovision
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: G09B 23/30 Anatomical models G09B23/281 - G09B23/288 take precedence

Abstract

A system for the controlled delivery of a desired agent to a fluid environment. A semipermeable container defines a fully enclosed cavity and is imperforate except for a plurality of pores for permitting fluid to flow from the fluid environment into the cavity. A quantity of a molecular complex is positioned in the cavity. The molecular complex comprises a macromolecule that is non-diffusable with respect to the container and a desired agent complexed to the macromolecule, the agent being capable of dissociating from the macromolecule over time. The pores of the container have a larger size in relation to the agent and the container is so constructed as to permit unimpeded passage of the agent through the pores. The concentration of the agent within the cavity is controlled by the equilibrium between the molecular complex and the agent within the cavity and the active agent is deliverable by the system to the fluid environment exclusively through the plurality of pores.

Claims

1. A system for the controlled delivery of a desired agent to a fluid environment comprising:

a semipermeable container defining a fully enclosed cavity and being imperforate except for a plurality of pores for permitting the flow of fluid between the fluid environment and said cavity; and

a quantity of molecular complex positioned in said cavity, said molecular complex comprising a macromolecule that is nondiffusable with respect to said container and a desired agent complexed to said macromolecule, said agent being capable of dissociating from said macromolecule over time, said pores having a larger size in relation to said agent and said container being so constructed as to permit unimpeded passage of said agent through said pores, wherein the concentration of said agent within said cavity is controlled by the equilibrium between said molecular complex and said agent within said cavity and said agent is deliverable by said system to the fluid environment exclusively through said plurality of pores.

2. The system according to claim 1, wherein said container is biodegradable.

3. The system according to claim 1, wherein said container comprises a semipermeable sheath.

4. The system of claim 1, wherein said sheath has a thickness of less than 50 microns.

5. The system of claim 1, wherein the diameter of said pores is less than 1,000 Angstroms.

6. The system of claim 1, wherein said container has a pore density between 100 and 10¹⁰ pores per square cm.

7. The system of claim 1, wherein said pores are sufficiently small to prevent the passage therethrough of said macromolecule.

8. The system of claim 1, wherein said container is transparent and said macromolecule is photostable.

9. The system of claim 1, wherein said macromolecule is inert.

10. The system of claim 1, wherein said macromolecule is selected from a group consisting of protein, cellulose, carbohydrates, rubber, high polymers and polymer arrays.

11. The system of claim 1, wherein said macromolecule is hydrophilic.

12. The system of claim 1, wherein said quantity of molecular complex constitutes a quantity of a first molecular complex with comprising a macromolecule of a first type complexed said desired agent, and said system further includes a quantity of a second molecular complex comprising a macromolecule of a second type that is nondiffusable with respect to said container and said desired agent complexed with said macromolecule of the second type, said desired agent being capable of dissociating from said macromolecule of the second type, and said first and second molecular complexes having different dissociation constants, wherein the concentration of said desired agent within said cavity is controlled by the equilibria between said desired agent and said first and second molecular complexes, respectively.

13. The system of claim 1, in combination with a fluid environment which contains a varying concentration of the desired agent, wherein the desired agent freely flows into and out of said cavity through said pores dependant upon the relative concentration of said agent within said cavity and in said environment.

14. The system of claim 1, in combination with a fluid environment which contains a second agent which can diffuse into said cavity through said pores for influencing the delivery of said desired agent to the environment, wherein said macromolecule is susceptible to competitive binding by said second agent and said second agent causes said desired agent to dissociate from said macromolecule and said second agent complexes with said macromolecule in place of said desired agent.

15. The system according to claim 1, wherein said desired agent is oxygen and said macromolecule complexes with oxygen molecules.

16. The system according to claim 1, wherein said macromolecule is hemoglobin and said desired agent is oxygen.