Apparatus for peritoneal dialysis

• US 4,618,343 A
• Filed: 09/12/1984
• Issued: 10/21/1986
• Est. Priority Date: 09/15/1983
• Status: Expired due to Fees

• Current Assignee: Fresenius AG (Fresenius SE & Co. KGaA)
• Original Assignee: Fresenius AG (Fresenius SE & Co. KGaA)
• Inventors: Polaschegg, Hans-Dietrich
• Primary Examiner(s): NOT, DEFINED
• Application Number:
  US06/649,873
• Time in Patent Office: 769 Days
• Field of Search: 604/29, 210/321.3, 210/321.4, 210/646, 210/647
• US Class Current: 604/29
• CPC Class Codes: A61M 1/1609 after use, i.e. downstream of dialyser
• CPC Class Codes: A61M 1/1639 linked by membranes
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/281 Instillation other than by gravity
• CPC Class Codes: A61M 1/284 Continuous flow peritoneal dialysis [CFPD]
• CPC Class Codes: A61M 2205/17 with redundant control systems
• CPC Class Codes: A61M 2205/331 used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection
• CPC Class Codes: A61M 2205/705 Testing of filters for leaks blood in dialysate A61M1/1692

Abstract

A peritoneal dialysis apparatus comprises a single lumen catheter through which in an intermittently operated circuit dialysis liquid is pumped from the peritoneal cavity of a patient and is then moved along in contact with a dialysis membrane, at which not only mass exchange but furthermore the withdrawal of ultrafiltrate is able to take place. On this membrane of the dialyzer a secondary dialysis takes place so that on the other side of the membrane dialysis liquid with an osmotically acting substance is moved in single-pass mode. Preferably the peritoneal dialysis circuit is made up of two dialyzers so placed that the one outlet of the first one is joined with a conventional dialysis apparatus and the outlet of the second dialyzer is joined with the catheter in the patient.

Claims

1. A peritoneal dialysis apparatus comprising:

at least one dialyzer with a membrane dividing a space therein into first and second chambers,

a single lumen catheter,

a first circuit joining the said first chamber with said catheter,

a second circuit,

means for preparing dialysis liquid and joined with said second chamber via said second circuit,

at least one pump in each of said first and second circuits,

supply and outlet ducts,

a dialysis filter joined with said supply and outlet ducts and having first and second chambers therein and so placed in said first circuit that with said supply duct and said outlet duct and the first chamber of the dialyzer the first chamber of the dialysis filter forms a closed circuit,

a connection duct joining said second chamber of said dialysis filter with said catheter,

a first pump placed in said supply duct,

a second pump placed in said outlet duct,

and a storage vessel joined with same at a point downstream from said second pump.

2. The apparatus as claimed in claim 1 comprising a means for withdrawing ultrafiltrate from the means for preparing dialysis liquid.

3. The apparatus as claimed in claim 1 comprising means for alternating operation of the first and second pumps, said pumps shutting off said supply and outlet ducts when said pumps are not in operation.

4. The apparatus as claimed in claim 3 wherein said first and second pumps are peristaltic pumps.

5. The apparatus as claimed in claim 2 wherein said means for preparing dialysis liquid is in the form of a constant-volume, balanced system.

6. The apparatus as claimed in claim 1 comprising a drip chamber connected in said supply duct downstream from the dialyzer, such drip chamber having a means for clearing air and a liquid level sensor.

7. The apparatus as claimed in claim 1 wherein said dialysis filter is placed in a circuit loop in which there is a substance whose molecular weight is above that of the cut-off limit of the dialyzer and of the dialysis filter.

8. The apparatus as claimed in claim 7 comprising a monitoring system including a monitoring unit and at least one sensor fitted to at least one of ducts selected from the group consisting of;

a duct joined with said dialysis filter, said outlet duct, said duct joining said dialyzer with said dialysis filter.

9. The apparatus as claimed in claim 1 comprising a substance in the said circuit joining said dialyzer with said filter, whose molecular weight is greater than the cut-off limit of the dialyzer but smaller than the cut-off limit of the dialysis filter.

10. The apparatus as claimed in claim 9 wherein said sensors are electrically joined with an ultrafiltration controller for control of the ultrafiltration pump on the basis of a comparison with the initial concentration of the substance for control of the ultrafiltration.

11. The apparatus as claimed in claim 1 comprising a vessel for additional liquid and a further duct joining same with said supply duct, said further duct having means for controlling the flow of liquid therethrough and being operated synchronously with said first pump.

12. The apparatus as claimed in claim 11 wherein said flow controlling means includes a hose clamp.

13. The apparatus as claimed in claim 11 comprising an ultrafiltration controller, a wire electrically joining the said flow controlling means with said controller, and an ultrafiltration pump joined with said controller, said controller causing said ultrafiltration pump to pump an amount of ultrafiltrate equal to an amount of liquid taken from said additional liquid vessel.

14. The apparatus as claimed in claim 12 comprising an exit duct connected with said dialysis filter, means detachably joining said connection duct with said exit duct in a resting condition, a controller electrically joined with said first and second pump for so controlling said pumps in a swilling and disinfection phase that the pumping rate of said first pump is greater than that of said second pump.

15. The apparatus as claimed in claim 14 comprising a sterilely hermetic, hydrophobic filter, a valve, an intermediate duct joining said hydrophobic filter and said valve in series between said second pump and said dialysis filter, said valve being electrically joined with said controller, which is electrically connected with said ultrafiltration pump.

16. The apparatus as claimed in claim 15 comprising a degassing vessel, controlling means for switching said apparatus into a checking phase in which said controller opens said valve and turns on said ultrafiltration pump, a pressure sensor fitted to said exit duct and a liquid level sensor placed on said degassing vessel for ascertaining a time pressure relation.

17. The apparatus as claimed in claim 15 wherein said means for preparing dialysis liquid is designed to be switched, while in a filling phase, into an open mode of operation, the valve is open to let off air, the first pump is kept turned on till liquid emerges at said hydrophobic filter and subsequently said second pump is put into operation with a pumping rate below that of said first pump.

18. The apparatus as claimed in claim 17 wherein said controller so operates the means for preparing dialysis liquid that after connection of the connection duct with the catheter of the patient a certain amount of liquid is discharged through the said connection duct and the catheter.

19. The apparatus as claimed in claim 11 wherein said flow controlling means includes a pump.

20. The apparatus as claimed in claim 1 wherein said means for preparing dialysis liquid includes a balanced chamber, a feed pump and means for operation of same in a cycle in step with operation of said first and second pumps so that spent dialysis liquid is displaced and filling takes place in a first cycle stroke and in a second stroke the content thereof is pumped through the said dialyzer using said feed pump, said first pump being operated in said second stroke and said second pump being operated in said first stroke.

21. A peritoneal dialysis apparatus comprising:

at least one dialyzer with a membrane dividing a space therein into a first chamber and a second chamber,

said first chamber being in a first circuit connected with a single lumen catheter means and a storage means and comprising a means for supplying a dialysis fluid, and

said second chamber being connected via a second circuit with a means for preparing said dialysis fluid,

said second circuit comprising pump means and a dialysis filter divided by a membrane into a first chamber and a second chamber,

said first chamber of said dialysis filter being in said first circuit, and

said second chamber of said dialysis filter being connected with said catheter means.

22. Apparatus as claimed in claim 21 wherein the dialyzer is a hemodialyzer comprising a cut-off limit of about 5,000-10,000 Dalton (molecular weight).

23. Apparatus as claimed in claim 21 wherein the dialysis filter is a hemofilter with a cut-off limit of 20,000-40,0000 Dalton.

24. Apparatus as claimed in claim 21, wherein the first circuit comprises a substance whose molecular weight is above that of the cut-off limit of the dialyzer and of the dialysis filter.

25. Apparatus as claimed in claim 24, wherein the second chamber of the dialysis filter is connected via an exit duct with the catheter means, said exit duct comprises a first sensor, the first chamber of the dialysis filter is connected via an outlet duct with the first chamber of the dialyzer, said outlet duct comprises a second sensor, and said first and second sensors are connected with a controlling means for controlling said substance.

26. Apparatus as claimed in claim 24 wherein the second chamber of the dialyzer comprises an outlet duct comprising a third sensor connected with said controlling means.

27. Apparatus as claimed in claim 25 wherein the second chamber of the dialyzer comprises an outlet duct comprising a third sensor connected with said controlling means.

28. Apparatus as claimed in claim 21 wherein the first circuit comprises a substance whose molecular weight is above that of the cut-off limit of the dialyzer, but smaller than the cut-off limit of the dialysis filter.

29. Apparatus as claimed in claim 28 wherein the exit duct comprises a fourth sensor connected with a means for controlling the ultrafiltration by comparing the starting concentration of the substance and the concentration of the substance during the treatment of the patient.