Capillary transport device having speed and meniscus control means

• US 4,618,476 A
• Filed: 10/31/1984
• Issued: 10/21/1986
• Est. Priority Date: 02/10/1984
• Status: Expired due to Term

• Current Assignee: Clinical Diagnostic Systems Inc.
• Original Assignee: Eastman Kodak Company
• Inventors: Columbus, Richard L.
• Primary Examiner(s): Turk, Arnold
• Application Number:
  US06/666,719
• Time in Patent Office: 720 Days
• Field of Search: 422/55, 422/58, 422/100, 422/50, 422/102, 204/409, 204/416
• US Class Current: 422/501
• CPC Class Codes: B01L 2200/0684 Venting, avoiding backpressure, avoid gas bubbles
• CPC Class Codes: B01L 2300/0645 Electrodes
• CPC Class Codes: B01L 2300/0825 Test strips
• CPC Class Codes: B01L 2300/0867 Multiple inlets and one sample wells, e.g. mixing, dilution
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 2400/086 using baffles or other fixed flow obstructions
• CPC Class Codes: B01L 3/502738 characterised by integrated valves microvalves F16K99/0001
• CPC Class Codes: B01L 3/502746 characterised by the means for controlling flow resistance, e.g. flow controllers, baffles B01L3/502738 takes precedence
• CPC Class Codes: Y10S 366/03 Micromixers: variable geometry from the pathway influences mixing/agitation of non-laminar fluid flow

Abstract

There is described a capillary transport device wherein the transport zone includes energy barriers such as ribs extending partway from one opposing surface to the other opposing surface of the zone, and slot means for preventing air entrapment, such means being in each energy barrier, or in every other energy barrier.

There is also described a method of providing a non-mixing junction between two miscible liquids.

Claims

1. In a liquid transport device having two opposed surfaces spaced apart a distance effective to create a capillary transport zone and to induce capillary flow between said surfaces of introduced liquid, said opposed surfaces being joined together at opposite edges of said zone, whereby flow of introduced liquid and air is confined between said edges, and access means for admitting liquids to said zone.

the improvement wherein one of said surfaces includes:

(a) spaced-apart energy barriers extending across a portion of a primary direction of travel of liquid through said zone between said edges, said barriers (i) having a height less than said distance between said surfaces and (ii) being effective to retard the rate of flow of liquid through said zone, and (b) means on said one sufface for initiating liquid flow past each of said energy barriers at a predetermined location between said edges.

2. A device as defined in claim 1, wherein said predetermined initiating location is approximately centered between said edges.

3. A device as defined in claim 1, wherein said energy barriers are spaced-apart ribs.

4. A device as defined in claim 1, and further including, between each of said barriers and extending across said portion of said primary direction of liquid travel, wall means having a height equal to said distance between said surfaces, whereby said surfaces are connected by said wall means;

and slot means formed in said wall means permitting liquid flow around said wall means.

5. A device as defined in claim 4, wherein said slot means of said wall means are displaced from said flow initiating means of said energy barriers in a direction generally perpendicular to said primary direction of travel.

6. A device as defined in claim 1, wherein said means on said one surface comprise a slot through at least every other one of said energy barriers.

7. A device as defined in claim 6, wherein each of said slots has at least a portion aligned with a portion of the next adjacent slot.

8. A device as defined in claim 6, wherein one-half of said energy barriers have only one of said slots and the other half have two of said slots displaced transversely, relative to said primary direction of liquid travel, from the location of said slots of said one-half of the barriers.