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Anti-ischaemic and antihypertensive 2-[pyrimidyloxy alhoxymethyl]-1,4-dihydropyridines

  • US 4,618,609 A
  • Filed: 06/05/1985
  • Issued: 10/21/1986
  • Est. Priority Date: 06/07/1984
  • Status: Expired due to Term
First Claim
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1. A dihydropyridine compound of the formula ##STR16## and a pharmaceutically acceptable acid addition salt thereof, wherein R is selected from the group consisting of 2-chlorophenyl and 2,3-dichlorophenyl;

  • R1 and R2 are each alkyl having from one to three carbon atoms;

    Y is selected from the group consisting of --(CH2)2 -- and --CH2 CH(CH3)--; and

    HET is selected from the group consisting of 2- and 4-pyrimidyl and substituted 2- and 4-pyrimidyl wherein said substituent is selected from the group consisting of carbamoyl, amino, alkoxy having from one to three carbon atoms, chloro, 2-aminoethylamino, 2-hydroxyethylamino, 2-pyridylmethylamino, 2,3-dihydroxypropylamino, 2-pyridylmethoxy, 1-methyl-2-imidazolylmethoxy and morpholino.

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