Method of producing a bone substitute material
First Claim
1. A method of producing a bone substitute material from collagen and a mineral component, said mineral component comprising apatite and/or hydroxyapatite and/or calcium phosphate ceramics, wherein an aqueous solution or a dispersion of cleaned collagen is mixed with a cross-linking agent of a quantity so as to result only in a partial cross-linking, whereby the quantity of said cross-linking agent is chosen such that the collagen is cross-linked only to such a degree that it retains its resorbability and its adsorptivity vis-a-vis bodily fluids and that the material does not generate undesirable side effects, and the mixture is lyophilized.
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Abstract
For producing the bone substitute material from collagen and hydroxyapatite, an aqueous solution of cleaned collagen is mixed with a cross-linking agent causing only a partial cross-linking, and the mixture is lyophilized.
The quantity of the cross-linking agent is chosen such that the collagen retains its resorbability and its absorptivity vis-a-vis bodily fluids, the material further showing no undesirable side effects.
Preferably less than 1% by weight of formaldehyde, one of the preferred cross-linking agents, is added, with reference to the dry weight of collagen, and sintered apatite grains with a diameter of 50-300 μm are used.
Such a bone substitute material is stronger and less tearable as previously known materials and insures a good promotion of the growth of own bone tissue and the substitution by it.
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Citations
13 Claims
- 1. A method of producing a bone substitute material from collagen and a mineral component, said mineral component comprising apatite and/or hydroxyapatite and/or calcium phosphate ceramics, wherein an aqueous solution or a dispersion of cleaned collagen is mixed with a cross-linking agent of a quantity so as to result only in a partial cross-linking, whereby the quantity of said cross-linking agent is chosen such that the collagen is cross-linked only to such a degree that it retains its resorbability and its adsorptivity vis-a-vis bodily fluids and that the material does not generate undesirable side effects, and the mixture is lyophilized.
Specification