Automatic fluid injector

• US 4,624,148 A
• Filed: 09/20/1985
• Issued: 11/25/1986
• Est. Priority Date: 09/20/1985
• Status: Expired due to Fees

• Current Assignee: Dynatech Precision Sampling Corp (Siemens AG)
• Original Assignee: Dynatech Precision Sampling Corp (Siemens AG)
• Inventors: Averette, Julius P.
• Primary Examiner(s): Levy, Stewart J.
• Assistant Examiner(s): Raevis, Robert R.
• Application Number:
  US06/778,194
• Time in Patent Office: 431 Days
• Field of Search: 73/864.81, 73/864.82, 73/864.21, 73/864.24, 73/864.22, 73/863.81
• US Class Current: 73/864.21
• CPC Class Codes: G01N 35/1079 with means for piercing stoppers or septums

Abstract

An apparatus, viz. an automatic fluid injector, useful for the injection of very small, accurately measured quantities of fluid specimens into various media, e.g., the inlets of modern analytical instruments. The improved apparatus combination embodies an injector feed assembly wherein the probe sub-assembly comprises the combination of (i) an outer rigid tubular needle of relatively large inside diameter, and (ii) an inner flexible tubular needle, one terminal end of which is concentrically contained within said outer rigid tubular needle and of sufficiently small outside diameter to form an annulus between the external surface of said inner flexible tubular needle and the internal surface of said outer rigid tubular needle, while the opposite end of said inner flexible tubular needle is communicated with the barrel of said syringe. The outer rigid tubular needle protects the inner flexible needle on thrust of the probe sub-assembly through the septum of a fluid specimen-containing vial. Thereafter, a terminal end of the inner flexible tubular needle can be moved, or thrust from within the protective interior to the outside of said outer rigid tubular needle, and extended to the very bottom of a fluid specimen-containing vial carried by the magazine such that essentially all of the fluid specimen can be removed from the vial, picked up by the probe sub-assembly, and delivered to the barrel of the syringe for injection.

Claims

1. In a fluid injector useful for the measurement and injection of preselected quantities of a fluid specimen into a medium such as an inlet to an analytical instrument wherein there is included the combination of (A) a syringe inclusive of a barrel into which a fluid specimen can be loaded, a needle mounted on an end of the barrel, and means for the displacement of the fluid specimen from said barrel via the dispensing end of the needle into said inlet, (B) an injector feed assembly comprises of a probe sub-assembly inclusive of a pair of concentrically mounted hollow needles for the pick up of said fluid specimen for filling the barrel of said syringe, and (C) a magazine for transporting one or more fluid specimen-containing septum sealed vials for pick up of fluid from a vial by the pairof hollow needles of said probe sub-assembly of said injector feed assembly for delivery to the barrel of said syringe via thrust of the hollow needles of said probe sub-assembly through the septem of a vial on pressurizing the contents of said vial by delivery of gas from a source through an annulus between the exterior surface of said inner hollow needle and the interior surface of said outer hollow needle of the pair of concentrically mounted hollow needles of said probe sub-assembly to produce flow of fluid specimen from said vial through the probe sub-assembly to the barrel of the syringe,

the improvement wherein the pair of concentrically mounted hollow needles of said probe sub-assembly of the injector feed assembly (B) is comprised of the combination of

(i) an outer rigid tubular needle of relatively large inside diameter, an end of which is directly affixed to said injector feed assembly, and

(ii) an inner flexible tubular needle, a terminal end and at least an adjacent portion thereof of which is contained within the bore of said outer rigid tubular needle and is of sufficiently small outside diameter to form an annulus between the external surface of said inner flexible tubular needle and the internal surface of said outer rigid tubular needle, while the opposite end of said inner flexible tubular needle is communicated with the barrel of said syringe,

whereby the outer rigid tubular needle protects the inner flexible needle when the pair of concentrically mounted hollow needles of the probe sub-assembly is thrust through the septum of a fluid specimen containing vial delivered by the magazine, and the inner flexible tubular needle can thereafter be thrust outside said outer rigid tubular needle and extended to the very bottom of a fluid specimen-containing vial such that on pressurization of the contents of the vial with a gas delivered via the annulus of the pair of concentrically mounted hollow needles of the probe sub-assembly essentially all of the fluid specimen can be removed from a vial, picked up by the probe sub-assembly, delivered to the barrel of the syringe, and injected into a medium via the dispensing end of the needle of the syringe.

2. The apparatus of claim 1 wherein the pair of concentric needles of the probe sub-assembly of the injector feed assembly (B) are mounted upon a pair of telescoping frames, a first frame provided with a base, an opening through said base, a plurality of shafts, spaced apart and parallelly oriented one with respect to the other supported upon said base, a second frame provided with a plurality of openings corresponding in number and orientation with the shafts on the base of said first frame within which said shafts of said first frame are guided and slidably mounted such that said second frame telescopes upon said first frame, a tubular barrel mounted and sealed within said second frame the central axis of which is aligned upon the central axis of the opening within the base of said first frame, a gas inlet to thetubular barrel, the outer rigid tubular needle of the pair of hollow needles of said probe sub-assembly being mounted, reciprocably movable, and sealed within said tubular barrel of said second frame, while the inner flexible tubular needle of the pair of needles is affixed to said second frame, passed through said tubular barrel and movable with said second frame such that it is reciprocably projectable into and out of the outer rigid hollow needle of the probe pair, the inner flexible tubular needle being shielded within the outer rigid tubular needle in an initial stage of movement in which said telescoping frames move together in unison to penetrate the septum of a specimen-containing vial by said outer needle, and thereafter in a second stage of movement the hollow flexible inner needle is projected outside said outer rigid hollow needle when the frames are telescoped and the hollow flexible inner needle extended to the lowermost portion of a fluid specimen-containing septum sealed vial delivered by the magazine for pick up of a fluid specimen therefrom for delivery to the syringe.

3. The apparatus of claim 2 wherein the injector feed assembly (B) further includes a probe seal assembly mounted between the said pair of telescoping frames and the magazine, the terminal end of the outer rigid hollow needle terminating within a lateral opening thereof within which it is sealed.

4. The apparatus of claim 3 wherein the probe seal assembly is valved, and contains an opening which intersects said lateral opening and within which a valve stem is mounted and in one position the end of the valve stem can be withdrawn from said lateral opening to permit passage therethrough of said outer rigid hollow needle, and in another position providing a means for purging, cleaning and drying said apparatus.

5. In a fluid injector useful for the measurement and injection of preselected quantities of a fluid specimen into a medium such as an inlet to an analytical instrument the combination comprising

(A) a syringe inclusive of a barrel into which a fluid specimen can be loaded, a needle mounted on the forward end of the barrel, and means for the displacement of the fluid specimen from said barrel, via the dispensing end of the needle into said inlet,

(B) an injector feed assembly inclusive of a probe sub-assembly which includes a pair of telescoping frames, a first frame provided with a base, an opening through said base, a plurality of shafts, spaced apart and parallelly oriented one with respect to the other supported upon said base, a second frame provided with a plurality of openings corresponding in number and orientation wtih the shafts on the base of said first frame within which said shafts of said first frame are guided and slidably mounted upon said first frame, locking means for locking together said first frame and said second frame so that said frames can be moved simultaneously, and unlocked such that said second frame can be telescoped upon said first frame, a tubular barrel mounted within and sealed inside said second frame the central axis of which is aligned upon the central axis of the opening within the base of said first frame, a gas inlet to the tubular barrel mounted and sealed within said second frame, a pair of concentrically mounted hollow needles, an outer rigid tubular needle of relatively large inside diameter mounted, reciprocably movable, and sealed within said tubular barrel of said second frame, an inner flexible tubular needle, a terminal end and at least an adjacent portion thereof which is contained within the opening through said outer rigid tubular needle, the inner flexible needle being affixed to said second frame and of sufficiently small outside diameter to form an annulus between the external surface of said inner flexible tubular needle and the internal surface of said outer rigid tubular needle, said annulus being communicated with the tubular barrel mounted within and sealed inside said second frame said with the gas inlet to said-tubular barrel, while the opposite end of said inner flexible tubular needle is communicated with the barrel of said syringe,

(C) a magazine for transporting one or more fluid specimen-containing septum sealed vials for pick up therefrom of a fluid specimen by the injector feed probe sub-assembly when the second frame in a first stage is moved concurrently with said first frame to thrust the outer hollow rigid needle through the septum of said specimen sealed fluid specimen-containing vial, and in a second stage of movement the second frame is telescoped upon said first frame to thrust and extend the inner hollow flexible needle to the very bottom of said vial, gas injected via the gas inlet to the tubular barrel and passed via the annulus between the external surface of said inner tubular needle and the internal surface of said outer rigid tubular needle to pressurize the fluid-specimen within said vial such that essentially all of the fluid specimen within said vial can be conveyed via the iner flexible needle to the barrel of the syringe.

6. The apparatus of claim 5 wherein the fluid injector further includes a valved probe seal assembly adjacent said first frame of the injector feed assembly, said valved probe seal assembly comprising a valve body containing a first opening extending through said valve body in axial alignment with the opening in the base of said first frame and the septum of a septum sealed fluid specimen-containing vial transported therebeneath by the magazine, a second opening intersecting said first opening and extending through said valve body to a junction to which a drain line can be adjoined, a valve stem an end of which is provided with a opening constituted of axial and lateral segments, said stem being reciprocably mounted within said second opening, a first position of which the lateral portion of the stem opening can be aligned upon said first opening of the block and the axial stem portion of the opening with the second opening such that a gas, a cleaning solvent, and drying gas, can be serially injected via the annulus formed between said inner flexible needle and outer rigid needle of the injector feed assembly (B), to purge and clean said annulus, and eliminate contaminants by passage through said adjoined drain line, and purge and clean the inner flexible needle of the injector feed assembly (B), and syringe, and dry same, and a second position wherein the stem can be withdrawn so that the probe can be projected through said first opening into a fluid specimen-containing vial to effect pick up of fluid specimen from said vial carried by the magazine.

7. The apparatus of claim 6 wherein the valved probe seal assembly is generally cylindrical in shape, said first opening is a lateral opening through a forward end of the valve body of said probe seal assembly, said second opening extends along the axis of the cylindrical shaped valve body, the forward portion of said axial opening within the valve body is provided with a tubular nozzle to which the drain line for carrying a solvent and purge gas can be adjoined, the rearward end of the cylindrical shaped valve body carries an adjoining tubular shaped housing which carries the stem, the forward end of which is extended from said housing through said axial opening, the housing carrying a spring which biases the stem in position for cleaning, purging, and drying said fluid injector, and the position of the stem can be reset in an opposite position to carry out the function of loading the syringe with fluid specimen obtained from said vial.

8. The apparatus of claim 7 wherein the stem of the valved probe seal assembly is an integral portion of a cylinder-piston unit, the stem is spring-biased in a first position for cleaning, purging and drying said fluid injector, and pneumatically repositioned and reset to carry out the function of loading the syringe with fluid specimen obtained from said vial.

9. In a fluid injector useful for the measurement and injection of preselected quantities of a fluid specimen into a medium such as an inlet to an analytical instrument wherein there is included the combination of (A) a syringe inclusive of a barrel into which a fluid specimen can be loaded, a needle mounted on an end of the barrel, and means for the displacement of the fluid specimen from said barrel via the dispensing end of the needle into said inlet, (B) an injector feed assembly comprised of a probe sub-assembly inclusive of a pair of concentrically mounted hollow needles for the pick up of said fluid specimen for filling the barrel of said syringe, and (C) a magazine for transporting one or more fluid specimen-containing septum sealed vials for pick up of fluid from said vials by the pair of hollow needles of said probe sub-assembly by said injector feed assembly for delivery to the barrel of said syringe via thrust of the hollow needles of said probe sub-assembly through the septum of a vial, the contents of the vial pressurized by delivery of gas from a source through an annulus between the exterior surface of said inner hollow needle and the interior surface of said outer hollow needle of the pair of concentrically mounted hollow needles of said probe sub-assembly to produce flow of fluid specimen from said vial through the probe sub-assembly to the barrel of the syringe,

the improvement wherein the pair of concentrically mounted hollow needles of said probe sub-assembly of the injector feed assembly (B) is comprised of the combination of

(i) an outer rigid tubular needle of relatively large inside diameter, an end of which is directly affixed to said injector feed assembly, and

(ii) an inner flexible tubular needle, a terminal end and at least an adjacent portion thereof of which is contained within the bore of said outer rigid tubular needle and is of sufficiently small outside diameter to form an annulus between the external surface of said inner flexible tubular needle and the internal surface of said outer rigid tubular needle, while the opposite end of said inner flexible tubular needle is communicated with the barrel of said syringe,

(iii) a pair of telescoping frames, a first frame provided with a base, an opening through said base, a plurality of shafts, spaced apart and parallelly oriented one with respect to the other supported upon said base, a second frame provided with a plurality of openings corresponding in number and orientation with the shafts on the base of said first frame within which said shafts of said first frame are guided and slidably mounted, locking means for locking together said first frame and said second frame and for unlocking said first frame from said second frame such that said second frame can in a first stage be locked to said first frame and moved simultaneously therewith and, in a second stage unlocked from said first frame and telescoped upon said first frame, a tubular barrel mounted and sealed within said second frame the central axis of which is aligned upon the central axis of the opening within the base of said first frame, a gas inlet to the tubular barrel, the outer rigid tubular needle of the pair of hollow needles of said probe sub-assembly being mounted, reciprocably movable and sealed within said tubular barrel of said second frame, while the inner flexible tubular needle of the pair of needles, is affixed to said second frame, passed through said tubular barrel and movable with said second frame such that it is reciprocably projectable into and out of the outer rigid hollow needle of the probe pair, the inner flexible tubular needle being shielded within the outer rigid tubular needle

whereby in said first stage of movement said frames are locked one to the other and moved together in unison, the inner flexible needle being transported within and shielded by the outer rigid needle of the concentric needles of the probe assembly to pentrate the septum of a specimen-containing vial by said outer needle, and thereafter in said second stage of continued movement the frames are unlocked one from the other and the second frame is telescoped upon said first frame so that the inner flexible needle is moved outside said outer rigid hollow needle and extended to the very bottom of said fluid specimen-containing vial such that on pressurization of the contents of the vial with a gas delivered via the annulus of the needles of the proble sub-assembly essentially all of the fluid specimen can be removed from said vial, picked up by the probe sub-assembly, delivered to the barrel of the syringe, and injected into a medium via the dispensing end of the needle of the syringe.

10. The apparatus of claim 9 wherein the pair of frames of the injector feed assembly are locked together via an inertia lock mechanism, unlocked, and telescoped on downward impact of a frame.