Drug delivery device for programmed delivery of beneficial drug
First Claim
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1. A dispensing device for delivering a beneficial medicine formulation to an environment of use, comprising:
- (a) a wall comprising in at least a part of a semipermeable composition permeable to the passage of an exterior fluid present in the environment of use and substantially impermeable to the passage of a beneficial medicine formulation, the wall surrounding and forming;
(b) a compartment;
(c) means in the compartment for increasing in size from a rested state to an expanded state for occupying more volume of the compartment;
(d) a medicine formulation in the compartment substantially coated around the means; and
,(e) means in the wall connecting the exterior of the device with the compartment for delivering the medicine from the device over time.
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Abstract
An osmotic dispensing device is disclosed for delivering a medicine to a biological environment of use. The device comprises a semipermeable wall surrounding a compartment with an osmotic passageway in the semipermeable wall connecting the outside of the device with the compartment. The compartment houses a medicine releasable carrier by a means for increasing in size for delivering the beneficial medicine from the device over time.
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Citations
22 Claims
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1. A dispensing device for delivering a beneficial medicine formulation to an environment of use, comprising:
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(a) a wall comprising in at least a part of a semipermeable composition permeable to the passage of an exterior fluid present in the environment of use and substantially impermeable to the passage of a beneficial medicine formulation, the wall surrounding and forming; (b) a compartment; (c) means in the compartment for increasing in size from a rested state to an expanded state for occupying more volume of the compartment; (d) a medicine formulation in the compartment substantially coated around the means; and
,(e) means in the wall connecting the exterior of the device with the compartment for delivering the medicine from the device over time. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A dispensing device for orally delivering a beneficial drug to a biological environment of use, comprising:
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(a) a shaped wall comprising a semipermeable composition permeable to the passage of an exterior fluid present in the environment of use, and substantially impermeable to the passage of drug, the wall surrounding and forming; (b) a compartment comprising a drug that surrounds and is carried by a hydrogel which hydrogel can expand from a rested to an expanded state in more than one direction in the presence of an exterior fluid that enters the compartment; and
,(c) a passageway in the wall communicating with the exterior of the device and the compartment for delivering the drug from the device at a controlled rate over time. - View Dependent Claims (15, 16, 17, 18, 19, 20)
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21. A method for delivering a medicine formulation to a fluid environment of use, wherein the method comprises:
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(a) admitting into the fluid environment of use a dispensing device comprising; (1) a wall comprising a semipermeable composition permeable to the passage of fluid present in the environment of use and substantially impermeable to a medicinal formulation surrounding and defining; (2) a compartment; (3) means in the compartment for increasing in volume and expanding outward toward the wall; (4) a medicine formulation in the compartment surrounding said means; (5) a first and second passageway in the wall communicating with the fluid environment and the compartment for delivering the medicine formulation from the device; (b) imbibing fluid from the environment into the compartment to form a solution containing the medicine formulation and for sorption by the means causing it to increase in volume and expand toward the wall and urge the medicine formulation through the passageway; and
,(c) delivering the medicine formulation through the passageway from the device to the fluid environment of use. - View Dependent Claims (22)
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Specification