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Method and apparatus for making mixtures of pharmaceutical liquids

  • US 4,625,494 A
  • Filed: 12/13/1985
  • Issued: 12/02/1986
  • Est. Priority Date: 04/28/1983
  • Status: Expired due to Term
First Claim
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1. Apparatus for the automatic preparation and accurate mixing of predetermined amounts of pharmaceutical liquid contamination-free in a closed system, comprising a plurality of closed supply containers containing the liquid components to be mixed, a supply tube leading from each of said containers, a cannula connecting each respective supply container and supply tube, a connector means having a plurality of connector inlets and a connector outlet with each of said connector inlets being in communication with said connector outlet, each of said supply tubes being connected to one of said connector inlets of said connector means, a sensor means in each of said supply tubes located between said supply container and said connector means, said sensor means including means to sense emptying of the respective supply container by sensing air in the respective supply tube, closure means in each of said supply tubes located between said sensor means and said connector means and operable to close off the respective supply tube when said sensor means senses emptying of the respective supply container, a vacuum chamber, a receptacle to be filled with the mixed pharmaceutical liquid, said receptacle being disposed within said vacuum chamber, a conduit leading from said outlet connection of said connector means and passing sealingly into said vacuum chamber for connection to said receptacle, said cannulas, said supply tubes, said connector means, said conduit, and said receptacle being formed as a single connected unit which is packaged in a sterile condition, a sealing means located along said conduit downstream of said closure means and said connector means to seal said conduit after said receptacle receives the pharmaceutical liquid from said supply containers, whereby the apparatus is operable to pass the liquid simultaneously from all of said closed supply containers to said receptacle in said vacuum chamber along a sealed flow path sealed from the outside atmosphere while air is prevented from entering said receptacle upon emptying of the respective supply container by the sensor means which operates the respective closure means to close off the respective supply tube when air is present in the respective supply tube upon emptying of the respective supply container, the apparatus thereby providing for automatic and exact filling of the receptacle under sterile conditions.

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