Compositions for combatting toxaemia

• US 4,626,536 A
• Filed: 10/19/1984
• Issued: 12/02/1986
• Est. Priority Date: 10/20/1983
• Status: Expired due to Term

• Current Assignee: ED. Geistlich Soehne AG Fuer Chemische Industrie
• Original Assignee: ED. Geistlich Soehne AG Fuer Chemische Industrie
• Inventors: Pfirrmann, Rolf W.
• Primary Examiner(s): Goldberg, Jerome D.
• Application Number:
  US06/662,887
• Time in Patent Office: 774 Days
• Field of Search: 424/246, 514/222
• US Class Current: 514/222.5
• CPC Class Codes: A61K 31/54 having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 39/02 Antidotes
• CPC Class Codes: C07D 285/18 1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Compounds of formula (I) ##STR1## [wherein R¹ represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms and R² represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms or a group of formula II ##STR2## in which R¹ is as defined above] and pharmaceutical compositions thereof may be administered to humans or warm-blooded animals to combat toxic proteins or peptides, e.g. venoms, fungal toxins and bacterial exotoxins, in the bloodstream.

Claims

1. A method of treatment of the human or warm-blooded animal body to combat toxic proteins or peptides in the bloodstream, said proteins or peptides being selected from the group consisting of fungal toxins, venoms and bacterial exotoxins, said method comprising administering to said infected body an effective amount for inactivating the toxic proteins or peptides of a compound of formula (I) ##STR7## wherein R¹ represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms and R² represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms or a group of formula II ##STR8## in which R¹ is as defined above.

2. A method as claimed in claim 1 wherein there is administered to said body a compound of formula (I) selected from the group consisting of taurolidine and taurultam.

3. A method as claimed in claim 1 wherein said compound of formula (I) is administered to said body intravenously.

4. A method as claimed in claim 3 wherein from 10 to 40 g of said compound of formula (I) is administered daily.