Cardiovascular prosthetic devices and implants with porous systems

• US 4,627,836 A
• Filed: 06/30/1983
• Issued: 12/09/1986
• Est. Priority Date: 05/09/1975
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: David C. Macgregor
• Inventors: MacGregor, David C.
• Primary Examiner(s): Swisher, Nancy A. B.
• Application Number:
  US06/486,796
• Time in Patent Office: 1,258 Days
• Field of Search: 3/1.4, 604/890-892, 604/84, 604/93, 128/334 R, 427/2
• US Class Current: 604/93.01
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61L 27/14 Macromolecular materials
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 33/022 Metal or alloys
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0565 Electrode heads
• CPC Class Codes: C08L 75/00 Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
• CPC Class Codes: Y10T 428/12042 Porous component

Abstract

Novel cardiovascular prosthetic devices or implants having many useful cardiovascular applications comprise a porous surface and a network of interconnected interstitial pores below the surface in fluid flow communication with the surface pores. Tissue forms a smooth thin adherent coating of self-determining thickness on the porous surface making it resistant to the formation of the blood clots normally associated with the presence of foreign bodies in the blood stream. The device has particular utility in heart valves, pacemaker electrodes, blood pumps, blood stream filters, an artificial pancreas, vascular access tubes, small and large bore vascular grafts, blood pump diaphragms and vascular and intracardiac patches.

Claims

1. A blood stream controlled release device comprising a hollow chamber containing a source of material to be released to blood and a porous surface of said chamber adapted to interface with a blood stream to establish communication between the blood stream and the interior of the chamber to permit said material release into the blood through a network of interconnected pores, said porous surface being formed of rigid material inert to blood and selected from metals, polymeric materials, ceramics and carbon, said porous surface having a porosity of at least 8% by volume up to the limit of coherence of the surface, an interstitial pore size of about 1 to about 1000 microns and a thickness up to 1 cm.

2. The device of claim 1 wherein said substance is a hormone or a drug.

3. The device of claim 1 wherein said porosity is about 10 to about 50% by volume and said thickness is about 25 to about 500 microns.

4. A method for the control of the release of substances into the blood stream, which comprises positioning a cardiovascular implant in the blood stream, said implant having a porous surface interfacing the blood and a network of interconnected pores in a subsurface in fluid flow communication with the porous surface, providing a source of a substance to be released into the blood in fluid flow communication with said subsurface on the opposite side thereof from said blood-interfacing surface, and releasing said substance through said subsurface and tissue growth on said blood-interfacing surface into said blood stream.

5. The method of claim 4 wherein said substance is a drug or a hormone.