Osmotic capsule
First Claim
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1. An osmotic capsule for the delivery at a controlled rate of a beneficial agent formulation to a fluid environment of use, the osmotic capsule comprising:
- (a) a lamina comprising in at least a part of a semipermeable composition that substantially maintains its integrity in the environment of use, is permeable to the passage of fluid present in the environment of use, and substantially impermeable to the passage of a beneficial agent formulation, the lamina surrounding;
(b) a capsule comprising a hydrophilic body and a matching cap telescopically joined to define a lumen;
(c) a beneficial agent formulation in the lumen, said formulation a member selected from the group consisting of solid, powdered, pulverized, micronized and particle formulations that form, when the osmotic capsule is in operation in the environment of use in the presence of fluid that enters the osmotic capsule, a member selected from the group consisting of a solution and suspension; and
,(d) at least one orifice through the lamina and the capsule communicating with the lumen and the exterior of the osmotic capsule for delivering the beneficial agent formulation from the osmotic capsule.
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Abstract
An osmotic capsule is disclosed for delivering a beneficial agent formulation to an environment of use. The osmotic capsule comprises an outer semipermeable wall surrounding and laminating an inner capsule wall formed of a different polymeric composition than the outer wall. The walls define an interior space containing the beneficial agent formulation. A passageway through the walls connects the exterior of the osmotic capsule with the interior of the osmotic capsule.
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Citations
26 Claims
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1. An osmotic capsule for the delivery at a controlled rate of a beneficial agent formulation to a fluid environment of use, the osmotic capsule comprising:
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(a) a lamina comprising in at least a part of a semipermeable composition that substantially maintains its integrity in the environment of use, is permeable to the passage of fluid present in the environment of use, and substantially impermeable to the passage of a beneficial agent formulation, the lamina surrounding; (b) a capsule comprising a hydrophilic body and a matching cap telescopically joined to define a lumen; (c) a beneficial agent formulation in the lumen, said formulation a member selected from the group consisting of solid, powdered, pulverized, micronized and particle formulations that form, when the osmotic capsule is in operation in the environment of use in the presence of fluid that enters the osmotic capsule, a member selected from the group consisting of a solution and suspension; and
,(d) at least one orifice through the lamina and the capsule communicating with the lumen and the exterior of the osmotic capsule for delivering the beneficial agent formulation from the osmotic capsule. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. An osmotic capsule for the delivery at a controlled rate of a beneficial agent formulation to a fluid environment of use, the osmotic capsule comprising:
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(a) a lamina comprising in at least a part a semipermeable composition that substantially maintains its integrity in the environment of use, is permeable to the passage of fluid present in the environment of use and is substantially impermeable to the passage of beneficial agent formulation, the lamina surrounding; (b) a one piece capsule comprising a hydrophilic lamina capsuling a lumen; (c) a beneficial agent formulation in the lumen, said formulation a member selected from the group consisting of solid, powdered pulverized, micronized and particle formulations that form, when the osmotic capsule is in operation in the environment of use in the presence of fluid that enters the osmotic capsule, a member elected from the group consisting of a solution and suspension; and
,(d) at least one orifice through the lamina and the capsule communicating with the lumen and the exterior of the osmotic capsule for delivering the beneficial agent formulation from the osmotic capsule. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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15. An osmotic capsule comprising a member selected from the group consisting of a single section and a two section capsule for the controlled delivery of a beneficial drug formulation to a biological environment of use, the osmotic capsule comprising:
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(a) a shaped wall comprising an inner lamina comprising a composition permeable to the passage of fluid present in the environment of use, and an outer lamina comprising a composition permeable to the passage of fluid present in the environment of use and substantially impermeable to the passage of drug formulation, the wall capsuling; (b) a compartment; (c) a dosage unit amount of a drug formulation in the compartment, said formulation a member selected from the group consisting of solid, powdered, pulverized, micronized and particle formulations that form, when the osmotic capsule is in operation in the environment of use and in the presence of fluid that enters the osmotic capsule, a member selected from the group consisting of a solution and suspension; and
,(d) at lease one orifice in the shaped wall communicating with the compartment and the exterior of the osmotic capsule for delivering the drug formulation to the environment of use over a prolonged period of time. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification