Device for the automatic insulin or glucose infusion in diabetic subjects, based on the continuous monitoring of the patient's glucose, obtained without blood withdrawal

• US 4,633,878 A
• Filed: 04/10/1984
• Issued: 01/06/1987
• Est. Priority Date: 04/19/1983
• Status: Expired due to Fees

• Current Assignee: Guiseppe Bombardieri
• Original Assignee: Guiseppe Bombardieri
• Inventors: Bombardieri, Guiseppe
• Primary Examiner(s): Coven, Edward M.
• Application Number:
  US06/598,787
• Time in Patent Office: 1,001 Days
• Field of Search: 128/642, 128/639, 128/637, 128/635, 128/632, 604/31, 604/190, 604/240, 204/403, 204/415
• US Class Current: 600/347
• CPC Class Codes: A61B 5/14528 invasively
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

A saline solution is pumped through a semi-permeable, hollow-fiber circuit implantable in a living body. A sensor determines the concentration of glucose in the solution. A microcomputer unit controls the supply of insulin and glucose to the body on the basis of the glucose concentration measurements. The hollow fibers form a filter through which only low molecular weight molecules may pass.

Claims

1. A device for the determination of the glucose content in the blood of a living body, which comprises a filter implantable in the subcutaneous tissue of said living body and composed of a circuit of biocompatible hollow fibers of polyacrylonitrile or polyethylene having a cut-off of 40,000 which are permeable to glucose but impermeable to the larger molecular weight components of the blood, means for circulating a saline solution through said filter located outside of the body whereby when said filter is implanted in said living body, glucose diffuses from the blood of said living body to said saline solution by dialysis and said saline solution after equilibrium is reached acquires the same concentration of glucose as in the blood of said living body;

a sensor located outside of the body and in communication with said filter for determining the concentration of glucose connected to said filter.

2. The device according to claim 1 wherein said circuit is spiral shaped.

3. The device according to claim 1 wherein said filter is implantable in the abdominal wall of said living body.

4. The device as claimed in claim 1 further comprising control means connected to said sensor and linked to said living body for selectively introducing insulin or glucose to said living body to counteract glucose present in said solution in said filter in amounts above a determined range and to counteract an insufficiency of glucose in said filter in amounts below said determined range, respectively.

5. The device according to claim 4 wherein said control means comprises a source of insulin, an insulin pump connected to said source of insulin and linked to said living body, a source of glucose, a glucose pump connected to said source of glucose and linked to said living body and microprocessor means coupling said sensor to said insulin pump and to said glucose pump for operating said insulin pump to supply insulin to said living body when said sensor determines a glucose concentration greater than a determined level and for operating said glucose pump to supply glucose to said living body when said sensor determines a glucose concentration less than a determined level.