Process for the preparation of hard tissue prosthetics
First Claim
1. A process for the preparation of a composite material containing from about 25 to about 75 percent by weight of a calcium phosphate biomaterial and about 75 to about 25 percent by weight of an α
- -amino acid polymer which comprises polymerizing in situ an N-carboxyanhydride of an α
-amino acid in the presence of a powdered calcium phosphate biomaterial, said polymerization taking place in an inert organic solvent, said process including the additional step of adding a pore-forming agent to the composite material prepared by said in situ polymerization.
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Abstract
An in situ polymerization process is disclosed whereby an α-amino acid N-carboxyanhydride is blended intimately and efficiently with one or more calcium phosphate biomaterials. The polymerization proceeds at ambient temperature and pressure without the need for initiators or surface modification of the calcium phosphate biomaterials. The resulting composite material may subsequently be ground and blended with a compatible water soluble pore-forming agent and then molded to form dense, shaped objects which may be made porous be leaching out said water soluble pore-forming agent. The resulting shaped objects may then be used as hard tissue prosthetics either alone or in conjunction with conventional prostheses.
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Citations
18 Claims
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1. A process for the preparation of a composite material containing from about 25 to about 75 percent by weight of a calcium phosphate biomaterial and about 75 to about 25 percent by weight of an α
- -amino acid polymer which comprises polymerizing in situ an N-carboxyanhydride of an α
-amino acid in the presence of a powdered calcium phosphate biomaterial, said polymerization taking place in an inert organic solvent, said process including the additional step of adding a pore-forming agent to the composite material prepared by said in situ polymerization. - View Dependent Claims (3, 5, 7, 9, 11, 13, 15, 17)
- -amino acid polymer which comprises polymerizing in situ an N-carboxyanhydride of an α
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2. A process for the preparation of a composite material containing from about 40 to about 60 percent by weight of a calcium phosphate biomaterial and from about 60 to about 40 percent by weight of an α
- -amino acid polymer which comprises polymerizing in situ an N-carboxyanhydride of an α
-amino acid in the presence of a powdered calcium phosphate biomaterial, said polymerization taking place in an inert organic solvent, said process including the additional step of adding a pore-forming agent to the composite material prepared by said in situ polymerization. - View Dependent Claims (4, 6, 8, 10, 12, 14, 16, 18)
- -amino acid polymer which comprises polymerizing in situ an N-carboxyanhydride of an α
Specification