Method and apparatus for removing arterial constriction

• US 4,636,195 A
• Filed: 04/04/1985
• Issued: 01/13/1987
• Est. Priority Date: 04/02/1982
• Status: Expired due to Term

• Current Assignee: Harvey Wolinsky
• Original Assignee: Harvey Wolinsky
• Inventors: Wolinsky, Harvey
• Primary Examiner(s): Pellegrino, Stephen C.
• Application Number:
  US06/720,453
• Time in Patent Office: 649 Days
• Field of Search: 604/49-54, 604/28, 604/43, 604/96-103, 604/266, 604/265, 604/269, 128/325, 128/344, 128/348.1
• US Class Current: 604/509
• CPC Class Codes: A61B 17/22 Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for dilators A61M29/00
• CPC Class Codes: A61B 2017/22038 with a guide wire
• CPC Class Codes: A61B 2017/22055 with three or more balloons
• CPC Class Codes: A61B 2017/22062 to be filled with liquid
• CPC Class Codes: A61B 2017/22084 stone- or thrombus-dissolving
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/575 substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
• CPC Class Codes: A61K 31/685 one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61L 29/041 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 25/00 Catheters; Hollow probes dilators A61M29/00; peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00 ; for measuring or testing A61B; materials for catheters A61L29/00
• CPC Class Codes: A61M 25/1011 Multiple balloon catheters
• CPC Class Codes: A61M 25/104 used for angioplasty

Abstract

A catheter is described with distal and proximate balloon segments expansible to produce a chamber around arterial plaque and a conduit for delivering solubilizing liquid into the chamber. The catheter may also contain a central expansible balloon to assist in forcing the liquid into the plaque and to compress the plaque. Several solubilizing liquids are described.

Claims

1. A cathether adapted for insertion into an artery for relieving arterial constriction caused by a body of plaque comprising a main catheter body having means including two spaced balloon elements adapted to be positioned adjacent respective proximate and distal ends of the plaque body and expansible against the arterial walls for providing a chamber about said plaque body so as to hold said main catheter body in place, means carried by said main catheter body for delivering a solution into said chamber for solubilizing said plaque body, and means including a third balloon element disposed intermediate said two spaced balloon elements and expansible for forcing said solution into said plaque body while compressing said plaque body.

2. A catheter according to either claim 1, each of said two spaced balloon elements having a length ranging from about 2 mm to 5 mm and being expansible to a diameter from about 2 mm to 5 mm.

3. A catheter according to claim 1 or claim 2, said third balloon element having a length ranging from about 10 mm to 5 mm and being expansible to a diameter ranging from about 2 mm to 5 mm.

4. A catheter according to claim 1, said two spaced balloon elements being expansible by fluid pressure and adapted to remain in a stable, expanded condition at about 5 atmospheres of pressure.

5. A method for relieving a constriction in an artery caused by a body of plaque which comprises the steps of:

1. inserting into the artery a catheter comprising a main catheter body having means including two spaced balloon elements adapted to be positioned adjacent respective proximate and distal ends of the plaque body and expansible to the arterial diameter of the constricted artery against the arterial walls for providing a chamber about said plaque body so as to hold said main catheter body in place, and means carried by said main catheter body for delivering a solution under pressure into said chamber and said plaque for solubilizing said plaque body,

2. inflating said two spaced balloon elements,

3. delivering a solubilizing solution into said chamber through said solution delivering means,

4. deflating said balloon elements, and

5. removing the catheter from the artery.

6. A method for relieving an arterial constriction caused by a body of plaque which comprises the steps of:

8. A method as in claim 6 wherein Steps 3 and 4 are performed simultaneously.

11. A method as in claim 8 wherein the phospholipid is a lecithin.

7. inserting into the artery a catheter comprising a main catheter body having means including two spaced balloon elements adapted to be positioned adjacent respective proximate and distal ends of the plaque body and expansible against the arterial walls for providing a chamber about said plaque body so as to hold said main catheter body in place, means carried by said main catheter body for delivering a solutin under pressure into said chamber and said plaque for solubilizing said plaque body and means including a third expansible balloon element disposed intermediate said two spaced balloon elements,inflating said two spaced balloon elements,delivering a solubilizing solution into said chamber through said colution delivering means,inflating said third balloon element,deflating said balloon elements,removing the catheter from the artery.

9. A method for relieving a constriction in an artery caused by a body of plaque which comprises the steps of:

1. inserting into the artery a catheter comprising a main catheter body having means including two spaced balloon elements adapted to be positioned adjacent respective proximate and distal ends of the plaque body and expansible to the arterial diameter of the constricted artery against the arterial walls for providing a chamber about said plaque body so as to hold said main catheter body in place, means carried by said main catheter body for delivering a solution under pressure into said chamber and said plaque for solubilizing said plaque body,

2. inflating said two spaced balloon elements,

3. delivering a solubilizing solution into said chamber through said solution delivering means,

12. A method as in claim 9 wherein the bile acid is selected from the group consisting of cholic, deoxycholic, taurocholic and glycocholic acids.

10. deflating said balloon elements, andremoving the catheter from the artery;

said solubilizing solution comprising an isotonic aqueous buffered mixture at a pH of from 7.2 to 7.6 of at least one phospholipid and at least one bile acid, having a solids content of from about 10% to 30% by volume and a water content of from 90% to 10% by volume the ratio of bile acid to phospholipid being from 50;

50 to 85;

15 by weight.

13. A method as in claims 8, 9 or 10 wherein the solubilizing solution additionally contains from about 20 to 400 μ

g/cc of solution of collagenase.